IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v444y2006i7117d10.1038_nature05336.html
   My bibliography  Save this article

Analysis of one million base pairs of Neanderthal DNA

Author

Listed:
  • Richard E. Green

    (Max-Planck Institute for Evolutionary Anthropology)

  • Johannes Krause

    (Max-Planck Institute for Evolutionary Anthropology)

  • Susan E. Ptak

    (Max-Planck Institute for Evolutionary Anthropology)

  • Adrian W. Briggs

    (Max-Planck Institute for Evolutionary Anthropology)

  • Michael T. Ronan

    (454 Life Sciences)

  • Jan F. Simons

    (454 Life Sciences)

  • Lei Du

    (454 Life Sciences)

  • Michael Egholm

    (454 Life Sciences)

  • Jonathan M. Rothberg

    (454 Life Sciences)

  • Maja Paunovic

    (Institute of Quaternary Paleontology and Geology, Croatian Academy of Sciences and Arts)

  • Svante Pääbo

    (Max-Planck Institute for Evolutionary Anthropology)

Abstract

Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes specific to anatomically fully modern humans. We have identified a 38,000-year-old Neanderthal fossil that is exceptionally free of contamination from modern human DNA. Direct high-throughput sequencing of a DNA extract from this fossil has thus far yielded over one million base pairs of hominoid nuclear DNA sequences. Comparison with the human and chimpanzee genomes reveals that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago. Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome-sequencing effort.

Suggested Citation

  • Richard E. Green & Johannes Krause & Susan E. Ptak & Adrian W. Briggs & Michael T. Ronan & Jan F. Simons & Lei Du & Michael Egholm & Jonathan M. Rothberg & Maja Paunovic & Svante Pääbo, 2006. "Analysis of one million base pairs of Neanderthal DNA," Nature, Nature, vol. 444(7117), pages 330-336, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7117:d:10.1038_nature05336
    DOI: 10.1038/nature05336
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05336
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05336?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Cyran, Krzysztof A. & Kimmel, Marek, 2010. "Alternatives to the Wright–Fisher model: The robustness of mitochondrial Eve dating," Theoretical Population Biology, Elsevier, vol. 78(3), pages 165-172.
    2. Haodong Ye & Jun Wen & Xingpeng Xu & Jiayu Li & Zhaopeng Lv & Yueping Su, 2024. "Study on the Geographical Spatial Characteristics of Forest Health Resorts in Fujian Province, China," Sustainability, MDPI, vol. 16(9), pages 1-13, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:444:y:2006:i:7117:d:10.1038_nature05336. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.