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Bacterial chromatin organization by H-NS protein unravelled using dual DNA manipulation

Author

Listed:
  • Remus T. Dame

    (Vrije Universiteit)

  • Maarten C. Noom

    (Vrije Universiteit)

  • Gijs J. L. Wuite

    (Vrije Universiteit)

Abstract

A new single-molecule approach is used to examine how a nucleoid-associated protein, H-NS, functions. H-NS sits between the two DNA molecules and is aligned along the helical pitch. H-NS does not act as a barrier to RNA polymerase, and its cooperative binding ensures that H-NS is dynamic enough to accommodate the movement of DNA-associated motor proteins, but stable enough to maintain DNA loops.

Suggested Citation

  • Remus T. Dame & Maarten C. Noom & Gijs J. L. Wuite, 2006. "Bacterial chromatin organization by H-NS protein unravelled using dual DNA manipulation," Nature, Nature, vol. 444(7117), pages 387-390, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7117:d:10.1038_nature05283
    DOI: 10.1038/nature05283
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    Cited by:

    1. Fatema-Zahra M. Rashid & Frédéric G. E. Crémazy & Andreas Hofmann & David Forrest & David C. Grainger & Dieter W. Heermann & Remus T. Dame, 2023. "The environmentally-regulated interplay between local three-dimensional chromatin organisation and transcription of proVWX in E. coli," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    2. Miloš Tišma & Florian Patrick Bock & Jacob Kerssemakers & Hammam Antar & Aleksandre Japaridze & Stephan Gruber & Cees Dekker, 2024. "Direct observation of a crescent-shape chromosome in expanded Bacillus subtilis cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Shuyu Li & Qinmeng Liu & Chongyi Duan & Jialin Li & Hengxi Sun & Lei Xu & Qiao Yang & Yao Wang & Xihui Shen & Lei Zhang, 2023. "c-di-GMP inhibits the DNA binding activity of H-NS in Salmonella," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Charles Cooper & Simon Legood & Rachel L. Wheat & David Forrest & Prateek Sharma & James R. J. Haycocks & David C. Grainger, 2024. "H-NS is a bacterial transposon capture protein," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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