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Structural basis for messenger RNA movement on the ribosome

Author

Listed:
  • Gulnara Yusupova

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire)

  • Lasse Jenner

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire)

  • Bernard Rees

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire)

  • Dino Moras

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire)

  • Marat Yusupov

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire)

Abstract

Getting the message Translocation of messenger RNA is one of the most important features of ribosome function and until now a complete structural picture of mRNA movement has been lacking. Now Yusupova et al. describe a series of structures that define how during initiation the mRNA's start codon is recognized, how rotation and movement of the mRNA in the 3′–5′ direction occurs in the post-initiation state, and how mRNA interactions differ during initiation and elongation. This is the first time the mRNA dynamics have been experimentally visualized.

Suggested Citation

  • Gulnara Yusupova & Lasse Jenner & Bernard Rees & Dino Moras & Marat Yusupov, 2006. "Structural basis for messenger RNA movement on the ribosome," Nature, Nature, vol. 444(7117), pages 391-394, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7117:d:10.1038_nature05281
    DOI: 10.1038/nature05281
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    Cited by:

    1. Chen Bao & Mingyi Zhu & Inna Nykonchuk & Hironao Wakabayashi & David H. Mathews & Dmitri N. Ermolenko, 2022. "Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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