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Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors

Author

Listed:
  • Shinya Yamada

    (Division of Virology, Department of Microbiology and Immunology
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

  • Yasuo Suzuki

    (Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
    Chubu University)

  • Takashi Suzuki

    (Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
    University of Shizuoka, School of Pharmaceutical Sciences and COE Program in the 21st Century)

  • Mai Q. Le

    (National Institute of Hygiene and Epidemiology)

  • Chairul A. Nidom

    (Avian Influenza Laboratory, Tropical Disease Centre, Airlangga University)

  • Yuko Sakai-Tagawa

    (Division of Virology, Department of Microbiology and Immunology
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

  • Yukiko Muramoto

    (Division of Virology, Department of Microbiology and Immunology
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

  • Mutsumi Ito

    (Division of Virology, Department of Microbiology and Immunology
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

  • Maki Kiso

    (Division of Virology, Department of Microbiology and Immunology
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

  • Taisuke Horimoto

    (Division of Virology, Department of Microbiology and Immunology
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

  • Kyoko Shinya

    (Tottori University)

  • Toshihiko Sawada

    (The United Graduate School of Agricultural Science, Gifu University)

  • Makoto Kiso

    (The United Graduate School of Agricultural Science, Gifu University)

  • Taiichi Usui

    (Shizuoka University)

  • Takeomi Murata

    (Shizuoka University)

  • Yipu Lin

    (MRC National Institute for Medical Research)

  • Alan Hay

    (MRC National Institute for Medical Research)

  • Lesley F. Haire

    (MRC National Institute for Medical Research)

  • David J. Stevens

    (MRC National Institute for Medical Research)

  • Rupert J. Russell

    (MRC National Institute for Medical Research
    University of St Andrews)

  • Steven J. Gamblin

    (MRC National Institute for Medical Research)

  • John J. Skehel

    (MRC National Institute for Medical Research)

  • Yoshihiro Kawaoka

    (Division of Virology, Department of Microbiology and Immunology
    Institute of Medical Science, University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
    University of Wisconsin-Madison)

Abstract

Pandemic potential The fact that the H5N1 bird flu virus circulating in Asia, Europe and Africa is unable to attach to human-type cell receptors has helped to prevent it from causing a worldwide epidemic of a human variant of the disease. Now a study of H5N1 isolates from some of the few humans that have been infected (from Vietnam and Thailand) has identified two mutations in a viral haemagglutinin that allow it to bind to both human and avian receptors. These mutations might be of use as molecular markers for assessing the pandemic potential of H5N1 field isolates.

Suggested Citation

  • Shinya Yamada & Yasuo Suzuki & Takashi Suzuki & Mai Q. Le & Chairul A. Nidom & Yuko Sakai-Tagawa & Yukiko Muramoto & Mutsumi Ito & Maki Kiso & Taisuke Horimoto & Kyoko Shinya & Toshihiko Sawada & Mako, 2006. "Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors," Nature, Nature, vol. 444(7117), pages 378-382, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7117:d:10.1038_nature05264
    DOI: 10.1038/nature05264
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    Cited by:

    1. Megan M. Slough & Rong Li & Andrew S. Herbert & Gorka Lasso & Ana I. Kuehne & Stephanie R. Monticelli & Russell R. Bakken & Yanan Liu & Agnidipta Ghosh & Alicia M. Moreau & Xiankun Zeng & Félix A. Rey, 2023. "Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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