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Structure of C3b in complex with CRIg gives insights into regulation of complement activation

Author

Listed:
  • Christian Wiesmann

    (Department of Protein Engineering)

  • Kenneth J. Katschke

    (Department of Immunology)

  • JianPing Yin

    (Department of Protein Engineering)

  • Karim Y. Helmy

    (Department of Immunology)

  • Micah Steffek

    (Department of Protein Chemistry)

  • Wayne J. Fairbrother

    (Department of Protein Engineering)

  • Scott A. McCallum

    (Department of Protein Engineering)

  • Lizette Embuscado

    (Department of Assay Technology)

  • Laura DeForge

    (Department of Assay Technology)

  • Philip E. Hass

    (Department of Protein Chemistry)

  • Menno van Lookeren Campagne

    (Department of Immunology)

Abstract

Fishing for complement Three papers in this issue report the first X-ray structures of C3b, the active form of human complement C3. The complement system is a family of blood serum proteins and cell-surface receptors that recognizes pathogens and unleashes the immune response against them. The powerhouse of the C3 protein is a thioester group: when activated it binds to an acceptor on the pathogen and marks it for destruction. There are similar thioesters in host cells too, so the C3 thioester has to be kept tightly under wraps. Knowledge of the structure of the active form of C3b is a step towards designing therapies to manipulate the complement system. Inappropriate activation of the complement system has been implicated in various diseases including arthritis, asthma, lupus erythematosus, autoimmune heart disease and multiple sclerosis.

Suggested Citation

  • Christian Wiesmann & Kenneth J. Katschke & JianPing Yin & Karim Y. Helmy & Micah Steffek & Wayne J. Fairbrother & Scott A. McCallum & Lizette Embuscado & Laura DeForge & Philip E. Hass & Menno van Loo, 2006. "Structure of C3b in complex with CRIg gives insights into regulation of complement activation," Nature, Nature, vol. 444(7116), pages 217-220, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7116:d:10.1038_nature05263
    DOI: 10.1038/nature05263
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    Cited by:

    1. Yi Duan & Huikuan Chu & Katharina Brandl & Lu Jiang & Suling Zeng & Nairika Meshgin & Eleni Papachristoforou & Josepmaria Argemi & Beatriz G. Mendes & Yanhan Wang & Hua Su & Weizhong Sun & Cristina Ll, 2021. "CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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