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Movement of ‘gating charge’ is coupled to ligand binding in a G-protein-coupled receptor

Author

Listed:
  • Yair Ben-Chaim

    (The Hebrew University
    The John Hopkins University Medical School)

  • Baron Chanda

    (University of Wisconsin)

  • Nathan Dascal

    (Tel Aviv University)

  • Francisco Bezanilla

    (University of Chicago)

  • Itzchak Parnas

    (The Hebrew University)

  • Hanna Parnas

    (The Hebrew University)

Abstract

Gate expectations Many extracellular chemical stimuli (hormones, neurotransmitters, odours and so on) are conveyed to the cell via G-protein coupled receptors (GPCRs). First step in these signal transduction processes is binding of ligand to the GPCR. These receptors span the cell membrane, but are not generally considered voltage sensitive. A new study of a prototypical GPCR, the m2 muscarinic receptor, shows that it displays charge movement associated currents analogous to 'gating currents' of voltage-gated channels, and that it is the charge movement that regulates binding affinity of the GPCR. The data indicate that GPCRs act as sensors for both transmembrane potential and external chemical signals.

Suggested Citation

  • Yair Ben-Chaim & Baron Chanda & Nathan Dascal & Francisco Bezanilla & Itzchak Parnas & Hanna Parnas, 2006. "Movement of ‘gating charge’ is coupled to ligand binding in a G-protein-coupled receptor," Nature, Nature, vol. 444(7115), pages 106-109, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7115:d:10.1038_nature05259
    DOI: 10.1038/nature05259
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    Cited by:

    1. Eyal Rozenfeld & Merav Tauber & Yair Ben-Chaim & Moshe Parnas, 2021. "GPCR voltage dependence controls neuronal plasticity and behavior," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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