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Cell death in the nervous system

Author

Listed:
  • Dale E. Bredesen

    (Buck Institute for Age Research
    University of California, San Francisco, 450 Parnassus)

  • Rammohan V. Rao

    (Buck Institute for Age Research)

  • Patrick Mehlen

    (Buck Institute for Age Research
    Apoptosis, Cancer and Development Laboratory, Université de Lyon, Centre Léon Bérard)

Abstract

Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease trigger neuronal cell death through endogenous suicide pathways. Surprisingly, although the cell death itself may occur relatively late in the course of the degenerative process, the mediators of the underlying cell-death pathways have shown promise as potential therapeutic targets.

Suggested Citation

  • Dale E. Bredesen & Rammohan V. Rao & Patrick Mehlen, 2006. "Cell death in the nervous system," Nature, Nature, vol. 443(7113), pages 796-802, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7113:d:10.1038_nature05293
    DOI: 10.1038/nature05293
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    Cited by:

    1. Abida Akter & Md. Golam Sadik & Md. Abdul Kader & Km Monirul Islam, 2016. "In Vitro Antioxidant Activity of Feronia Limonia Bark Relevant to the Treatment of Oxidative Stress Mediated Neurodegenerative Disorders," World Scientific Research, Asian Online Journal Publishing Group, vol. 3(1), pages 62-69.
    2. Jin, Jun & Xu, Fei & Liu, Zhilong & Shuai, Jianwei & Li, Xiang, 2024. "Quantifying the underlying landscape, entropy production and biological path of the cell fate decision between apoptosis and pyroptosis," Chaos, Solitons & Fractals, Elsevier, vol. 178(C).

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