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The roles of intracellular protein-degradation pathways in neurodegeneration

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  • David C. Rubinsztein

    (Cambridge Institute for Medical Research, Addenbrooke's Hospital)

Abstract

Many late-onset neurodegenerative diseases, including Parkinson's disease and Huntington's disease, are associated with the formation of intracellular aggregates by toxic proteins. It is therefore crucial to understand the factors that regulate the steady-state levels of these 'toxins', at both the synthetic and degradation stages. The degradation pathways acting on such aggregate-prone cytosolic proteins include the ubiquitin–proteasome system and macroautophagy. Dysfunction of the ubiquitin–proteasome or macroautophagy pathways might contribute to the pathology of various neurodegenerative conditions. However, enhancing macroautophagy with drugs such as rapamycin could offer a tractable therapeutic strategy for a number of these diseases.

Suggested Citation

  • David C. Rubinsztein, 2006. "The roles of intracellular protein-degradation pathways in neurodegeneration," Nature, Nature, vol. 443(7113), pages 780-786, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7113:d:10.1038_nature05291
    DOI: 10.1038/nature05291
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    Cited by:

    1. Abida Akter & Md. Golam Sadik & Md. Abdul Kader & Km Monirul Islam, 2016. "In Vitro Antioxidant Activity of Feronia Limonia Bark Relevant to the Treatment of Oxidative Stress Mediated Neurodegenerative Disorders," World Scientific Research, Asian Online Journal Publishing Group, vol. 3(1), pages 62-69.
    2. Xing-Ding Zhang & Lin Qi & Jun-Chao Wu & Zheng-Hong Qin, 2013. "DRAM1 Regulates Autophagy Flux through Lysosomes," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-14, May.

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