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A network dysfunction perspective on neurodegenerative diseases

Author

Listed:
  • Jorge J. Palop

    (University of California)

  • Jeannie Chin

    (University of California)

  • Lennart Mucke

    (University of California)

Abstract

Patients with Alzheimer's disease or other neurodegenerative disorders show remarkable fluctuations in neurological functions, even during the same day. These fluctuations cannot be caused by sudden loss or gain of nerve cells. Instead, it is likely that they reflect variations in the activity of neural networks and, perhaps, chronic intoxication by abnormal proteins that the brain is temporarily able to overcome. These ideas have far-reaching therapeutic implications.

Suggested Citation

  • Jorge J. Palop & Jeannie Chin & Lennart Mucke, 2006. "A network dysfunction perspective on neurodegenerative diseases," Nature, Nature, vol. 443(7113), pages 768-773, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7113:d:10.1038_nature05289
    DOI: 10.1038/nature05289
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    Cited by:

    1. Gosak, Marko & Markovič, Rene & Marhl, Marko, 2012. "The role of neural architecture and the speed of signal propagation in the process of synchronization of bursting neurons," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 391(8), pages 2764-2770.

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