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Bidirectional control of CNS capillary diameter by pericytes

Author

Listed:
  • Claire M. Peppiatt

    (University College London)

  • Clare Howarth

    (University College London)

  • Peter Mobbs

    (University College London)

  • David Attwell

    (University College London)

Abstract

Brain imaging: seeing red Non-invasive imaging techniques that reveal those parts of the brain that are active by detecting the increased blood flow that supplies extra glucose and oxygen to active nerve cells. Until now it was assumed that blood flow is controlled by the contraction of smooth muscle around large blood vessels called arterioles. Now an additional level of blood flow control has been discovered, downstream of arterioles. This control is exerted by the pericytes, small cells that wrap around the capillaries close to active nerve cells. The pericytes, that act by squeezing the capillary to reduce blood flow though it, are likely to contribute to the signals detected in brain imaging techniques, and could also provide a target for therapy in disorders of brain blood flow.

Suggested Citation

  • Claire M. Peppiatt & Clare Howarth & Peter Mobbs & David Attwell, 2006. "Bidirectional control of CNS capillary diameter by pericytes," Nature, Nature, vol. 443(7112), pages 700-704, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7112:d:10.1038_nature05193
    DOI: 10.1038/nature05193
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    Cited by:

    1. Airi Jo-Watanabe & Toshiki Inaba & Takahiro Osada & Ryota Hashimoto & Tomohiro Nishizawa & Toshiaki Okuno & Sayoko Ihara & Kazushige Touhara & Nobutaka Hattori & Masatsugu Oh-Hora & Osamu Nureki & Tak, 2024. "Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Ujwal Chaudhary & Bin Xia & Stefano Silvoni & Leonardo G Cohen & Niels Birbaumer, 2017. "Brain–Computer Interface–Based Communication in the Completely Locked-In State," PLOS Biology, Public Library of Science, vol. 15(1), pages 1-25, January.

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