IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v443y2006i7112d10.1038_nature05164.html
   My bibliography  Save this article

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

Author

Listed:
  • Ivan Ahel

    (Cancer Research UK, London Research Institute, Clare Hall Laboratories)

  • Ulrich Rass

    (Cancer Research UK, London Research Institute, Clare Hall Laboratories)

  • Sherif F. El-Khamisy

    (University of Sussex
    Faculty of Pharmacy, Ain Shams University)

  • Sachin Katyal

    (St. Jude Children's Research Hospital)

  • Paula M. Clements

    (University of Sussex)

  • Peter J. McKinnon

    (St. Jude Children's Research Hospital)

  • Keith W. Caldecott

    (University of Sussex)

  • Stephen C. West

    (Cancer Research UK, London Research Institute, Clare Hall Laboratories)

Abstract

Aprataxin cleans up unfinished DNA ligation intermediates. By cleaving off an adenylate group at the site of a ligatable nick, aprataxin generates ends that can then be re-ligated. This suggests that neurodegeneration results from the accumulation of these intermediates in post-mitotic neuronal cells.

Suggested Citation

  • Ivan Ahel & Ulrich Rass & Sherif F. El-Khamisy & Sachin Katyal & Paula M. Clements & Peter J. McKinnon & Keith W. Caldecott & Stephen C. West, 2006. "The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates," Nature, Nature, vol. 443(7112), pages 713-716, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7112:d:10.1038_nature05164
    DOI: 10.1038/nature05164
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05164
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05164?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ross J. Hill & Nazareno Bona & Job Smink & Hannah K. Webb & Alastair Crisp & Juan I. Garaycoechea & Gerry P. Crossan, 2024. "p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Lonnie P. Swift & B. Christoffer Lagerholm & Lucy R. Henderson & Malitha Ratnaweera & Hannah T. Baddock & Blanka Sengerova & Sook Lee & Abimael Cruz-Migoni & Dominic Waithe & Christian Renz & Helle D., 2024. "SNM1A is crucial for efficient repair of complex DNA breaks in human cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:443:y:2006:i:7112:d:10.1038_nature05164. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.