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Identification of nesfatin-1 as a satiety molecule in the hypothalamus

Author

Listed:
  • Shinsuke Oh-I

    (Gunma University Graduate School of Medicine)

  • Hiroyuki Shimizu

    (Gunma University Graduate School of Medicine)

  • Tetsurou Satoh

    (Gunma University Graduate School of Medicine)

  • Shuichi Okada

    (Gunma University Graduate School of Medicine)

  • Sachika Adachi

    (Saitama University)

  • Kinji Inoue

    (Saitama University)

  • Hiroshi Eguchi

    (Teijin Pharma Limited, Asahigaoka)

  • Masanori Yamamoto

    (Teijin Pharma Limited, Asahigaoka)

  • Toshihiro Imaki

    (Gunma University Graduate School of Medicine)

  • Koushi Hashimoto

    (Gunma University Graduate School of Medicine)

  • Takafumi Tsuchiya

    (Gunma University Graduate School of Medicine)

  • Tsuyoshi Monden

    (Gunma University Graduate School of Medicine)

  • Kazuhiko Horiguchi

    (Gunma University Graduate School of Medicine)

  • Masanobu Yamada

    (Gunma University Graduate School of Medicine)

  • Masatomo Mori

    (Gunma University Graduate School of Medicine)

Abstract

Enough is enough Appetite is regulated — at least in part — in the hypothalamus, the brain region that links the nervous and endocrine systems. A screen for appetite-regulating molecules has now identified a fragment of the protein nucleobindin 2, dubbed nesfatin-1, as a satiety molecule produced in the hypothalamus. When nesfatin-1 is injected into the brain, rats eat less and lose weight. When nesfatin-1 is blocked, animals eat more. Nesfatin-1 is therefore a possible target for antiobesity drugs.

Suggested Citation

  • Shinsuke Oh-I & Hiroyuki Shimizu & Tetsurou Satoh & Shuichi Okada & Sachika Adachi & Kinji Inoue & Hiroshi Eguchi & Masanori Yamamoto & Toshihiro Imaki & Koushi Hashimoto & Takafumi Tsuchiya & Tsuyosh, 2006. "Identification of nesfatin-1 as a satiety molecule in the hypothalamus," Nature, Nature, vol. 443(7112), pages 709-712, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7112:d:10.1038_nature05162
    DOI: 10.1038/nature05162
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    Cited by:

    1. Jagoda Kruszewska & Hanna Laudy-Wiaderny & Michał Kunicki, 2022. "Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients—The Debate Is Still Open," IJERPH, MDPI, vol. 19(4), pages 1-25, February.
    2. Lucius K Caldwell & Andrew L Pierce & Larry G Riley & Christine A Duncan & James J Nagler, 2014. "Plasma Nesfatin-1 Is Not Affected by Long-Term Food Restriction and Does Not Predict Rematuration among Iteroparous Female Rainbow Trout (Oncorhynchus mykiss)," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.

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