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Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

Author

Listed:
  • John C. Kash

    (University of Washington School of Medicine)

  • Terrence M. Tumpey

    (Influenza Branch, DVRD, NCID, Centers for Disease Control and Prevention)

  • Sean C. Proll

    (Washington National Primate Research Center)

  • Victoria Carter

    (Washington National Primate Research Center)

  • Olivia Perwitasari

    (University of Washington School of Medicine)

  • Matthew J. Thomas

    (Washington National Primate Research Center)

  • Christopher F. Basler

    (Mount Sinai School of Medicine)

  • Peter Palese

    (Mount Sinai School of Medicine)

  • Jeffery K. Taubenberger

    (Armed Forces Institute of Pathology
    Laboratory of Infectious Diseases, NIAID, NIH)

  • Adolfo García-Sastre

    (Mount Sinai School of Medicine)

  • David E. Swayne

    (Agricultural Research Laboratory, US Department of Agriculture)

  • Michael G. Katze

    (University of Washington School of Medicine
    Washington National Primate Research Center)

Abstract

The 1918 pandemic The availability of a reconstructed 1918 influenza pandemic virus means that it is now possible to study host reactions to the infection, and to use such information to inform public health measures and in the development of new antivirals. A study in mice shows that viruses containing all eight genes from the pandemic strain provoked much greater inflammatory and cell death responses than viruses containing subsets of the genes. This extreme response may be a factor in the severe immunopathology characteristic of the 1918 infection.

Suggested Citation

  • John C. Kash & Terrence M. Tumpey & Sean C. Proll & Victoria Carter & Olivia Perwitasari & Matthew J. Thomas & Christopher F. Basler & Peter Palese & Jeffery K. Taubenberger & Adolfo García-Sastre & D, 2006. "Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus," Nature, Nature, vol. 443(7111), pages 578-581, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7111:d:10.1038_nature05181
    DOI: 10.1038/nature05181
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    Cited by:

    1. Ida M Friberg & Ann Lowe & Catriona Ralli & Janette E Bradley & Joseph A Jackson, 2011. "Temporal Anomalies in Immunological Gene Expression in a Time Series of Wild Mice: Signature of an Epidemic?," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-8, May.
    2. C. Justin Cook & Jason M. Fletcher & Angela Forgues, 2019. "Multigenerational Effects of Early-Life Health Shocks," Demography, Springer;Population Association of America (PAA), vol. 56(5), pages 1855-1874, October.

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