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Reassembly of shattered chromosomes in Deinococcus radiodurans

Author

Listed:
  • Ksenija Zahradka

    (INSERM Site Necker, U571
    Ruder Boskovic Institute)

  • Dea Slade

    (INSERM Site Necker, U571)

  • Adriana Bailone

    (Institut de Génétique et Microbiologie, CNRS UMR8621, CEA LRC42V, Université Paris-Sud)

  • Suzanne Sommer

    (Institut de Génétique et Microbiologie, CNRS UMR8621, CEA LRC42V, Université Paris-Sud)

  • Dietrich Averbeck

    (Institut Curie, Section Recherche, UMR 2027 CNRS, Centre Universitaire de Paris-Sud)

  • Mirjana Petranovic

    (Ruder Boskovic Institute)

  • Ariel B. Lindner

    (INSERM Site Necker, U571)

  • Miroslav Radman

    (INSERM Site Necker, U571
    Mestrovicevo setaliste bb)

Abstract

Pull yourself together Deinococcus radiodurans, isolated in the 1950s from canned meat that had gone off despite being sterilized by high-dose radiation, can recover from radiation exposure even though the DNA damage caused completely fragments the genome. How does it achieve this remarkable feat? It is known to carry multiple copies of its genome and quick and effective DNA repair mechanisms. A new study now shows that first, DNA fragments with regions of complementary sequence find each other and initiate synthesis by a DNA polymerase to form long single-stranded ends on the fragments. Then, complementary single-strand tails pair, to regenerate long double-stranded DNA molecules that are processed into the original circular genome.

Suggested Citation

  • Ksenija Zahradka & Dea Slade & Adriana Bailone & Suzanne Sommer & Dietrich Averbeck & Mirjana Petranovic & Ariel B. Lindner & Miroslav Radman, 2006. "Reassembly of shattered chromosomes in Deinococcus radiodurans," Nature, Nature, vol. 443(7111), pages 569-573, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7111:d:10.1038_nature05160
    DOI: 10.1038/nature05160
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    Cited by:

    1. Huizhi Lu & Zijing Chen & Teng Xie & Shitong Zhong & Shasha Suo & Shuang Song & Liangyan Wang & Hong Xu & Bing Tian & Ye Zhao & Ruhong Zhou & Yuejin Hua, 2024. "The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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