IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v443y2006i7110d10.1038_nature05092.html
   My bibliography  Save this article

p16INK4a induces an age-dependent decline in islet regenerative potential

Author

Listed:
  • Janakiraman Krishnamurthy

    (The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine)

  • Matthew R. Ramsey

    (The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine)

  • Keith L. Ligon

    (Brigham and Women's Hospital and Harvard Medical School)

  • Chad Torrice

    (The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine)

  • Angela Koh

    (Joslin Diabetes Center and Harvard Medical School)

  • Susan Bonner-Weir

    (Joslin Diabetes Center and Harvard Medical School)

  • Norman E. Sharpless

    (The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine)

Abstract

Stem cell ageing In this issue, three separate labs report the discovery of a protein that regulates ageing specifically in stem cells. This helps answer a fundamental question: why do mammalian progenitor cells gradually lose their ability to divide and generate new cells as they grow old? Norman Sharpless and colleagues generated a knockout mouse lacking tumour suppressor p16INK4a, a protein involved in cell cycle control and known to be expressed in an age-dependent manner. Studying its role in regeneration of the blood, pancreas and brain, the three groups separately found that p16INK4a is not only a biomarker, but an effector of ageing. By comparing the effect of elevated or reduced p16INK4a expression in mice, they found that p16INK4a halts proliferation of stem cells, but only in older mice. Taken together, the work suggests that p16INK4a reduces cancer incidence via its tumour suppressor action, at the same time contributing to ageing by reducing stem cell function. The work also suggests that type 2 diabetes might be linked to the failure of the pancreatic islets to renew, and that blocking this protein in certain tissues might combat some effects of ageing.

Suggested Citation

  • Janakiraman Krishnamurthy & Matthew R. Ramsey & Keith L. Ligon & Chad Torrice & Angela Koh & Susan Bonner-Weir & Norman E. Sharpless, 2006. "p16INK4a induces an age-dependent decline in islet regenerative potential," Nature, Nature, vol. 443(7110), pages 453-457, September.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7110:d:10.1038_nature05092
    DOI: 10.1038/nature05092
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05092
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05092?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Li, Ting & Anderson, James J., 2009. "The vitality model: A way to understand population survival and demographic heterogeneity," Theoretical Population Biology, Elsevier, vol. 76(2), pages 118-131.
    2. Yudong Fu & Fan Jiang & Xiao Zhang & Yingyi Pan & Rui Xu & Xiu Liang & Xiaofen Wu & Xingqiang Li & Kaixuan Lin & Ruona Shi & Xiaofei Zhang & Dominique Ferrandon & Jing Liu & Duanqing Pei & Jie Wang & , 2024. "Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:443:y:2006:i:7110:d:10.1038_nature05092. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.