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Centrosome polarization delivers secretory granules to the immunological synapse

Author

Listed:
  • Jane C. Stinchcombe

    (Sir William Dunn School of Pathology)

  • Endre Majorovits

    (Wellcome Trust Centre for Human Genetics)

  • Giovanna Bossi

    (Sir William Dunn School of Pathology)

  • Stephen Fuller

    (Wellcome Trust Centre for Human Genetics)

  • Gillian M. Griffiths

    (Sir William Dunn School of Pathology)

Abstract

Special delivery Cytotoxic T lymphocytes are an important part of the immune system, killing targets by releasing the content of secretory lysosomes ('lytic' granules) at the immunological synapse. It's generally assumed that, by analogy to melanocytes, lytic granules travel by short plus-end directed microtubules from the microtubule organizing centre to the actin cytoskeleton in order to reach the immunological synapse. But no. Cytotoxic T lymphocytes have now been found to be independent of actin or plus-end microtubule motors, instead using a novel mechanism controlled by movement of the centrosome to deliver the lethal lytic granules.

Suggested Citation

  • Jane C. Stinchcombe & Endre Majorovits & Giovanna Bossi & Stephen Fuller & Gillian M. Griffiths, 2006. "Centrosome polarization delivers secretory granules to the immunological synapse," Nature, Nature, vol. 443(7110), pages 462-465, September.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7110:d:10.1038_nature05071
    DOI: 10.1038/nature05071
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    Cited by:

    1. Mitchell S. Wang & Yuesong Hu & Elisa E. Sanchez & Xihe Xie & Nathan H. Roy & Miguel Jesus & Benjamin Y. Winer & Elizabeth A. Zale & Weiyang Jin & Chirag Sachar & Joanne H. Lee & Yeonsun Hong & Minsoo, 2022. "Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Joachim Hanna & Flavio Beke & Louise M. O’Brien & Chrysa Kapeni & Hung-Chang Chen & Valentina Carbonaro & Alexander B. Kim & Kamal Kishore & Timon E. Adolph & Mikkel-Ole Skjoedt & Karsten Skjoedt & Ma, 2022. "Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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