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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Author

Listed:
  • Cheryl L. Day

    (Doris Duke Medical Research Institute, University of KwaZulu Natal
    Massachusetts General Hospital and Division of AIDS, Harvard Medical School
    The Peter Medawar Building for Pathogen Research, Oxford University)

  • Daniel E. Kaufmann

    (Massachusetts General Hospital and Division of AIDS, Harvard Medical School)

  • Photini Kiepiela

    (Doris Duke Medical Research Institute, University of KwaZulu Natal)

  • Julia A. Brown

    (Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School)

  • Eshia S. Moodley

    (Doris Duke Medical Research Institute, University of KwaZulu Natal)

  • Sharon Reddy

    (Doris Duke Medical Research Institute, University of KwaZulu Natal)

  • Elizabeth W. Mackey

    (Massachusetts General Hospital and Division of AIDS, Harvard Medical School)

  • Joseph D. Miller

    (Emory University School of Medicine
    Immunology, Emory University School of Medicine)

  • Alasdair J. Leslie

    (The Peter Medawar Building for Pathogen Research, Oxford University)

  • Chantal DePierres

    (Doris Duke Medical Research Institute, University of KwaZulu Natal)

  • Zenele Mncube

    (Doris Duke Medical Research Institute, University of KwaZulu Natal)

  • Jaikumar Duraiswamy

    (Emory University School of Medicine
    Immunology, Emory University School of Medicine)

  • Baogong Zhu

    (Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School)

  • Quentin Eichbaum

    (Massachusetts General Hospital and Division of AIDS, Harvard Medical School)

  • Marcus Altfeld

    (Massachusetts General Hospital and Division of AIDS, Harvard Medical School)

  • E. John Wherry

    (The Wistar Institute)

  • Hoosen M. Coovadia

    (Doris Duke Medical Research Institute, University of KwaZulu Natal)

  • Philip J. R. Goulder

    (Doris Duke Medical Research Institute, University of KwaZulu Natal
    Massachusetts General Hospital and Division of AIDS, Harvard Medical School
    The Peter Medawar Building for Pathogen Research, Oxford University)

  • Paul Klenerman

    (The Peter Medawar Building for Pathogen Research, Oxford University)

  • Rafi Ahmed

    (Emory University School of Medicine
    Immunology, Emory University School of Medicine)

  • Gordon J. Freeman

    (Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School)

  • Bruce D. Walker

    (Doris Duke Medical Research Institute, University of KwaZulu Natal
    Massachusetts General Hospital and Division of AIDS, Harvard Medical School
    Howard Hughes Medical Institute)

Abstract

HIV and immunity Blocking a protein called PD-1 (programmed death 1) might provide a way to boost the immune function of T cells crippled by HIV infection. A study published earlier this year showed that blocking of PD-1 function in virally infected mice could restore the function of exhausted T cells and help fight infection. Now the phenomenon has been found to occur in humans. The T cells in HIV patients were found to have many more PD-1 receptors on their surface than is normal; the degree of PD-1 production correlates with markers of disease progression including the extent to which T cells are disabled and the levels of virus within the body. An antibody that blocks this receptor promotes the immune response to HIV in laboratory experiments, suggesting that a similar strategy might work to fight the disease in humans.

Suggested Citation

  • Cheryl L. Day & Daniel E. Kaufmann & Photini Kiepiela & Julia A. Brown & Eshia S. Moodley & Sharon Reddy & Elizabeth W. Mackey & Joseph D. Miller & Alasdair J. Leslie & Chantal DePierres & Zenele Mncu, 2006. "PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression," Nature, Nature, vol. 443(7109), pages 350-354, September.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7109:d:10.1038_nature05115
    DOI: 10.1038/nature05115
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    Cited by:

    1. Norma Rallón & Marcial García & Javier García-Samaniego & Alfonso Cabello & Beatriz Álvarez & Clara Restrepo & Sara Nistal & Miguel Górgolas & José M Benito, 2018. "Expression of PD-1 and Tim-3 markers of T-cell exhaustion is associated with CD4 dynamics during the course of untreated and treated HIV infection," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-14, March.
    2. Becca Asquith, 2008. "The Evolutionary Selective Advantage of HIV-1 Escape Variants and the Contribution of Escape to the HLA-Associated Risk of AIDS Progression," PLOS ONE, Public Library of Science, vol. 3(10), pages 1-10, October.

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