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The cells and logic for mammalian sour taste detection

Author

Listed:
  • Angela L. Huang

    (University of California at San Diego)

  • Xiaoke Chen

    (University of California at San Diego)

  • Mark A. Hoon

    (National Institutes of Health)

  • Jayaram Chandrashekar

    (University of California at San Diego)

  • Wei Guo

    (University of California at San Diego)

  • Dimitri Tränkner

    (University of California at San Diego)

  • Nicholas J. P. Ryba

    (National Institutes of Health)

  • Charles S. Zuker

    (University of California at San Diego)

Abstract

Acid test In recent years the molecular mechanisms of three of the five basic taste sensations in mammals have been identified: sweet, bitter and umami (monosodium glutamate). The others, sour (or 'acid') and salt, were elusive. Now the cells and a candidate receptor mediating sour taste have been identified. PKD2L1, a polycystic kidney disease-like ion channel, is proposed to act as part of the mammalian sour taste receptor, and shown to define the population of cells on the tongue required for sour taste. PKD2L1 is also found in neurons around the central canal of the spinal cord that trigger action potentials in response to a fall in extracellular pH. These cells could be long-sought components of the cerebrospinal fluid chemosensory system. This work points to a common basis for acid sensing in very different physiological settings. On the cover, tongue tissue with taste receptor cells labelled red for sour sensing and green for sweet, umami and bitter.

Suggested Citation

  • Angela L. Huang & Xiaoke Chen & Mark A. Hoon & Jayaram Chandrashekar & Wei Guo & Dimitri Tränkner & Nicholas J. P. Ryba & Charles S. Zuker, 2006. "The cells and logic for mammalian sour taste detection," Nature, Nature, vol. 442(7105), pages 934-938, August.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7105:d:10.1038_nature05084
    DOI: 10.1038/nature05084
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    Cited by:

    1. Ziyu Liang & Courtney E. Wilson & Bochuan Teng & Sue C. Kinnamon & Emily R. Liman, 2023. "The proton channel OTOP1 is a sensor for the taste of ammonium chloride," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Ninghai Gan & Weizhong Zeng & Yan Han & Qingfeng Chen & Youxing Jiang, 2024. "Structural mechanism of proton conduction in otopetrin proton channel," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Ashkan A. Shahbandi & Ezen Choo & Robin Dando, 2018. "Receptor Regulation in Taste: Can Diet Influence How We Perceive Foods?," J, MDPI, vol. 1(1), pages 1-10, October.

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