IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v442y2006i7105d10.1038_nature05028.html
   My bibliography  Save this article

NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

Author

Listed:
  • Ayumu Tashiro

    (The Salk Institute for Biological Studies
    Norwegian University of Science and Technology)

  • Vladislav M. Sandler

    (The Salk Institute for Biological Studies)

  • Nicolas Toni

    (The Salk Institute for Biological Studies)

  • Chunmei Zhao

    (The Salk Institute for Biological Studies)

  • Fred H. Gage

    (The Salk Institute for Biological Studies)

Abstract

Well connected New neurons are continuously added to the adult brain but how this affects brain function is unclear. By developing a new single-cell gene knock-out technique, Tashiro et al. show that new neurons are selected for survival depending on their synaptic input. This provides a possible mechanism for the building of new yet consistent neuronal circuits during learning and memory. In the image above, new neurons in adult dentate gyrus are visualized by retrovirus-mediated expression of green fluorescence protein. The dentate granule and CA3 pyramidal cell layers were visualized by immunostaining for NeuN.

Suggested Citation

  • Ayumu Tashiro & Vladislav M. Sandler & Nicolas Toni & Chunmei Zhao & Fred H. Gage, 2006. "NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus," Nature, Nature, vol. 442(7105), pages 929-933, August.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7105:d:10.1038_nature05028
    DOI: 10.1038/nature05028
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05028
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05028?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zhao, Liang, 2008. "Rethinking basically Economic Assumption on Individual Behavior from Empirical Viewpoints of Evolution and Behavior," MPRA Paper 11152, University Library of Munich, Germany.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:442:y:2006:i:7105:d:10.1038_nature05028. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.