IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v442y2006i7105d10.1038_nature04985.html
   My bibliography  Save this article

Mechanism limiting centrosome duplication to once per cell cycle

Author

Listed:
  • Meng-Fu Bryan Tsou

    (Stanford University, Department of Genetics, Stanford University Medical School)

  • Tim Stearns

    (Stanford University, Department of Genetics, Stanford University Medical School)

Abstract

Centrosomes: two's a crowd The centrosome is duplicated just once per cell cycle so that there is one centrosome at the beginning of the cell cycle and two in mitosis. Defects in this process can cause genome instability and even cancer. An in vitro study points to a strikingly similarity between the way cells control centrosome duplication and chromosome segregation. The pair of centrioles in the centrosome disengage at the end of mitosis, a process requiring separase, a protease involved in sister chromatid separation at mitosis. The separated centrioles are a substrate for duplication in the next cell cycle. Newly duplicated centrioles are paired, so they cannot duplicate again until passage through mitosis, when they are freed to duplicate by separase-mediated disengagement. This work reveals a common mechanism behind the two cellular processes that result in exact duplication once per cycle.

Suggested Citation

  • Meng-Fu Bryan Tsou & Tim Stearns, 2006. "Mechanism limiting centrosome duplication to once per cell cycle," Nature, Nature, vol. 442(7105), pages 947-951, August.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7105:d:10.1038_nature04985
    DOI: 10.1038/nature04985
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04985
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04985?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Devashish Dwivedi & Daniela Harry & Patrick Meraldi, 2023. "Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Aurélien Perrier & Nadège Guiglielmoni & Delphine Naquin & Kevin Gorrichon & Claude Thermes & Sonia Lameiras & Alexander Dammermann & Philipp H. Schiffer & Maia Brunstein & Julie C. Canman & Julien Du, 2024. "Maternal inheritance of functional centrioles in two parthenogenetic nematodes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:442:y:2006:i:7105:d:10.1038_nature04985. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.