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An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

Author

Listed:
  • Fajun Yang

    (Massachusetts General Hospital Cancer Center
    Department of Cell Biology)

  • Bryan W. Vought

    (Department of Biological Chemistry and Molecular Pharmacology)

  • John S. Satterlee

    (Massachusetts General Hospital Cancer Center)

  • Amy K. Walker

    (Massachusetts General Hospital Cancer Center
    Harvard Medical School)

  • Z.-Y. Jim Sun

    (Department of Biological Chemistry and Molecular Pharmacology)

  • Jennifer L. Watts

    (Washington State University)

  • Rosalie DeBeaumont

    (Massachusetts General Hospital Cancer Center
    Department of Cell Biology)

  • R. Mako Saito

    (Massachusetts General Hospital Cancer Center
    Harvard Medical School
    Dartmouth Medical School)

  • Sven G. Hyberts

    (Department of Biological Chemistry and Molecular Pharmacology)

  • Shaosong Yang

    (Massachusetts General Hospital Cancer Center
    Department of Cell Biology
    ERDC-CERL)

  • Christine Macol

    (Massachusetts General Hospital Cancer Center
    Department of Cell Biology
    Prince George's Community College)

  • Lakshmanan Iyer

    (Harvard University)

  • Robert Tjian

    (Department of Molecular and Cell Biology, UC Berkeley)

  • Sander van den Heuvel

    (Massachusetts General Hospital Cancer Center
    Harvard Medical School
    Utrecht University)

  • Anne C. Hart

    (Massachusetts General Hospital Cancer Center
    Harvard Medical School)

  • Gerhard Wagner

    (Department of Biological Chemistry and Molecular Pharmacology)

  • Anders M. Näär

    (Massachusetts General Hospital Cancer Center
    Department of Cell Biology)

Abstract

A subunit of the ARC/Mediator co-activator complex is a key effector of the SREBP transcription factor during regulation of lipid homeostasis in human cells and Caenorhabditis elegans. The SREBP activation domain directly targets a KIX domain on ARC105/MED15

Suggested Citation

  • Fajun Yang & Bryan W. Vought & John S. Satterlee & Amy K. Walker & Z.-Y. Jim Sun & Jennifer L. Watts & Rosalie DeBeaumont & R. Mako Saito & Sven G. Hyberts & Shaosong Yang & Christine Macol & Lakshman, 2006. "An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis," Nature, Nature, vol. 442(7103), pages 700-704, August.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7103:d:10.1038_nature04942
    DOI: 10.1038/nature04942
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    Cited by:

    1. Alex Z. Kadhim & Ben Vanderkruk & Samantha Mar & Meixia Dan & Katarina Zosel & Eric E. Xu & Rachel J. Spencer & Shugo Sasaki & Xuanjin Cheng & Shannon L. J. Sproul & Thilo Speckmann & Cuilan Nian & Ro, 2024. "Transcriptional coactivator MED15 is required for beta cell maturation," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Jin-Hyuck Jeong & Jun-Seok Han & Youngae Jung & Seung-Min Lee & So-Hyun Park & Mooncheol Park & Min-Gi Shin & Nami Kim & Mi Sun Kang & Seokho Kim & Kwang-Pyo Lee & Ki-Sun Kwon & Chun-A. Kim & Yong Ryo, 2023. "A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Changnan Wang & Bingying Wang & Taruna Pandey & Yong Long & Jianxiu Zhang & Fiona Oh & Jessica Sima & Ruyin Guo & Yun Liu & Chao Zhang & Shaeri Mukherjee & Michael Bassik & Weichun Lin & Huichao Deng , 2022. "A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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