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Enzymatic activation of voltage-gated potassium channels

Author

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  • Yajamana Ramu

    (University of Pennsylvania)

  • Yanping Xu

    (University of Pennsylvania)

  • Zhe Lu

    (University of Pennsylvania)

Abstract

Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials1. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference between the solutions separated by the plasma membrane. The search for so-called voltage-gated channel activators is motivated in part by the growing importance of such agents in clinical pharmacology. Here we report the apparent activation of voltage-gated K+ (Kv) channels by a sphingomyelinase.

Suggested Citation

  • Yajamana Ramu & Yanping Xu & Zhe Lu, 2006. "Enzymatic activation of voltage-gated potassium channels," Nature, Nature, vol. 442(7103), pages 696-699, August.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7103:d:10.1038_nature04880
    DOI: 10.1038/nature04880
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    Cited by:

    1. Dandan Lei & Yixiang Wang & Qixiang Zhang & Shuqi Wang & Lei Jiang & Zhen Zhang, 2025. "High-performance solid-state proton gating membranes based on two-dimensional hydrogen-bonded organic framework composites," Nature Communications, Nature, vol. 16(1), pages 1-12, December.

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