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P2X receptors as cell-surface ATP sensors in health and disease

Author

Listed:
  • Baljit S. Khakh

    (Medical Research Council Laboratory of Molecular Biology
    University of California Los Angeles)

  • R. Alan North

    (University of Manchester)

Abstract

P2X receptors are membrane ion channels activated by the binding of extracellular adenosine triphosphate (ATP). For years their functional significance was consigned to distant regions of the autonomic nervous system, but recent work indicates several further key roles, such as afferent signalling, chronic pain, and in autocrine loops of endothelial and epithelial cells. P2X receptors have a molecular architecture distinct from other ion channel protein families, and have several unique functional properties.

Suggested Citation

  • Baljit S. Khakh & R. Alan North, 2006. "P2X receptors as cell-surface ATP sensors in health and disease," Nature, Nature, vol. 442(7102), pages 527-532, August.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7102:d:10.1038_nature04886
    DOI: 10.1038/nature04886
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    Cited by:

    1. Cheng Shen & Yuqing Zhang & Wenwen Cui & Yimeng Zhao & Danqi Sheng & Xinyu Teng & Miaoqing Shao & Muneyoshi Ichikawa & Jin Wang & Motoyuki Hattori, 2023. "Structural insights into the allosteric inhibition of P2X4 receptors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Lingyun Jia & Jingyue Bai & Dongdong Guan & Kun Sun & Qingsong Jiao & Hanqing Feng, 2016. "Extracellular ATP: a potential molecule regulating the defence response of plants to biotic stresses - a review," Plant Protection Science, Czech Academy of Agricultural Sciences, vol. 52(4), pages 221-228.

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