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Endothelial tubes assemble from intracellular vacuoles in vivo

Author

Listed:
  • Makoto Kamei

    (Laboratory of Molecular Genetics)

  • W. Brian Saunders

    (Texas A&M University System Health Science Center)

  • Kayla J. Bayless

    (Texas A&M University System Health Science Center)

  • Louis Dye

    (Microscopy and Imaging Core, National Institute of Child Health and Human Development, National Institutes of Health)

  • George E. Davis

    (Texas A&M University System Health Science Center)

  • Brant M. Weinstein

    (Laboratory of Molecular Genetics)

Abstract

Tubular cells Epithelial tubes are important structural components in many different tissues, including the vascular system, where because of the interest in angiogenesis inhibitors as anticancer drugs, they are pharmacologically important too. It has been difficult to establish their exact mechanism of formation. Now high resolution time-lapse imaging of blood vessel formation in living (and conveniently transparent) zebrafish shows that the lumen of the blood vessels is formed by coalescence of intracellular vacuoles, followed by fusion to the plasma membrane. The study finally provides in vivo confirmation of the century-old fusion model for endothelial lumen formation, and finally lays to rest alternative models and concerns about cell culture artefacts.

Suggested Citation

  • Makoto Kamei & W. Brian Saunders & Kayla J. Bayless & Louis Dye & George E. Davis & Brant M. Weinstein, 2006. "Endothelial tubes assemble from intracellular vacuoles in vivo," Nature, Nature, vol. 442(7101), pages 453-456, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7101:d:10.1038_nature04923
    DOI: 10.1038/nature04923
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    Cited by:

    1. Eunnyung Bae & Ping Huang & Gaёlle Müller-Greven & Dolores Hambardzumyan & Andrew Edward Sloan & Amy S. Nowacki & Nicholas Marko & Cathleen R. Carlin & Candece L. Gladson, 2022. "Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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