IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v442y2006i7099d10.1038_nature04917.html
   My bibliography  Save this article

A germline-specific class of small RNAs binds mammalian Piwi proteins

Author

Listed:
  • Angélique Girard

    (Watson School of Biological Sciences
    Ecole Nationale Supérieure des Mines de Paris)

  • Ravi Sachidanandam

    (Watson School of Biological Sciences)

  • Gregory J. Hannon

    (Watson School of Biological Sciences)

  • Michelle A. Carmell

    (Watson School of Biological Sciences)

Abstract

A new type of RNAi In RNA interference, small RNAs (siRNAs or miRNAs) act to regulate gene expression. They serve as specificity factors that direct the RISC (RNA-induced silencing) complex to the complementary mRNA targets. A major component of RISC is a protein of the Argonaute family. Two groups have now identified a new class of small RNAs that interact with one Argonaute subfamily, the Piwi class. These testis-specific small RNAs, called 'piRNAs', are slightly longer than the previously described small RNAs. The function of the piRNAs is not yet known, but they might be involved in sperm production.

Suggested Citation

  • Angélique Girard & Ravi Sachidanandam & Gregory J. Hannon & Michelle A. Carmell, 2006. "A germline-specific class of small RNAs binds mammalian Piwi proteins," Nature, Nature, vol. 442(7099), pages 199-202, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7099:d:10.1038_nature04917
    DOI: 10.1038/nature04917
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04917
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04917?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xiaolong Lv & Wen Xiao & Yana Lai & Zhaozhen Zhang & Hongdao Zhang & Chen Qiu & Li Hou & Qin Chen & Duanduan Wang & Yun Gao & Yuanyuan Song & Xinjia Shui & Qinghua Chen & Ruixin Qin & Shuang Liang & W, 2023. "The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Birgit Stallmeyer & Clara Bühlmann & Rytis Stakaitis & Ann-Kristin Dicke & Farah Ghieh & Luisa Meier & Ansgar Zoch & David MacKenzie MacLeod & Johanna Steingröver & Özlem Okutman & Daniela Fietz & Adr, 2024. "Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Ariane Lismer & Sarah Kimmins, 2023. "Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    4. Liina Nagirnaja & Alexandra M. Lopes & Wu-Lin Charng & Brian Miller & Rytis Stakaitis & Ieva Golubickaite & Alexandra Stendahl & Tianpengcheng Luan & Corinna Friedrich & Eisa Mahyari & Eloise Fadial &, 2022. "Diverse monogenic subforms of human spermatogenic failure," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Susanne Bornelöv & Benjamin Czech & Gregory J. Hannon, 2022. "An evolutionarily conserved stop codon enrichment at the 5′ ends of mammalian piRNAs," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    6. Gangming Zhang & Chunwei Zheng & Yue-he Ding & Craig Mello, 2024. "Casein kinase II promotes piRNA production through direct phosphorylation of USTC component TOFU-4," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:442:y:2006:i:7099:d:10.1038_nature04917. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.