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Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography

Author

Listed:
  • Jun Liu

    (Florida State University)

  • Dianne W. Taylor

    (Florida State University)

  • Elena B. Krementsova

    (University of Vermont)

  • Kathleen M. Trybus

    (University of Vermont)

  • Kenneth A. Taylor

    (Florida State University)

Abstract

Myosin V: special delivery There is growing interest in the mechanisms that cells use to deliver specific components to correct sites. Myosin motor proteins perform many of these transport roles. Now Liu et al. have determined the three-dimensional structure of an inhibited state of myosin V: the structure suggests a novel mechanism for solving the problem of returning a molecular motor from its destination to its starting position. When myosin V has no cargo it has a compact structure that binds to rapidly treadmilling actin filaments. In a separate paper, Thirumurugan et al. show that, in the absence of cargo, the cargo-binding domain of myosin V binds to a specific target on its own motor domain to inhibit its own movement along the actin track and weaken its binding to actin. These two papers reveal the elegant method used by cells to keep cargo transport under control.

Suggested Citation

  • Jun Liu & Dianne W. Taylor & Elena B. Krementsova & Kathleen M. Trybus & Kenneth A. Taylor, 2006. "Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography," Nature, Nature, vol. 442(7099), pages 208-211, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7099:d:10.1038_nature04719
    DOI: 10.1038/nature04719
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    Cited by:

    1. Goldman, Carla & Sena, Elisa T., 2009. "The dynamics of cargo driven by molecular motors in the context of asymmetric simple exclusion processes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(17), pages 3455-3464.
    2. Weimin Li & Angdi Li & Bing Yu & Xiaoxiao Zhang & Xiaoyan Liu & Kate L. White & Raymond C. Stevens & Wolfgang Baumeister & Andrej Sali & Marion Jasnin & Liping Sun, 2024. "In situ structure of actin remodeling during glucose-stimulated insulin secretion using cryo-electron tomography," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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