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Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF

Author

Listed:
  • Haitao Li

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Serge Ilin

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Wooikoon Wang

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Elizabeth M. Duncan

    (Rockefeller University)

  • Joanna Wysocka

    (Rockefeller University)

  • C. David Allis

    (Rockefeller University)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

Abstract

Histones decoded Four papers in this issue tackle the hot topic of chromatin remodelling, specifically, how methyl marks on chromatin are 'read' by the proteins that interact with them. Two report on BPTF (bromodomain and PHD domain transcription factor), a subunit of NURF, the nucleosome remodelling factor. It contains a domain known as a PHD finger, which is shown to bind to histone H3 trimethylated at lysine 4 (H3K4) and to maintain proper activity at developmentally critical HOX genes. The accompanying structural study of the complex explains how the site specificity for H3K4 is achieved. The two other papers reveal that the PHD domain of tumour suppressor ING2 also recognizes trimethylated H3K4, and link the histone mark to repression of transcription. The four papers together establish certain PHD finger domains as previously unrecognized chromatin-binding modules. In a News and Views piece, Peter B. Becker discusses what these papers tell us about the function of the chemical modifications of histone tails.

Suggested Citation

  • Haitao Li & Serge Ilin & Wooikoon Wang & Elizabeth M. Duncan & Joanna Wysocka & C. David Allis & Dinshaw J. Patel, 2006. "Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF," Nature, Nature, vol. 442(7098), pages 91-95, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7098:d:10.1038_nature04802
    DOI: 10.1038/nature04802
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    Cited by:

    1. Dimitrios Spiliotopoulos & Andrea Spitaleri & Giovanna Musco, 2012. "Exploring PHD Fingers and H3K4me0 Interactions with Molecular Dynamics Simulations and Binding Free Energy Calculations: AIRE-PHD1, a Comparative Study," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-13, October.

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