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Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential

Author

Listed:
  • Yousheng Shu

    (Kavli Institute for Neuroscience, Yale University School of Medicine)

  • Andrea Hasenstaub

    (Kavli Institute for Neuroscience, Yale University School of Medicine)

  • Alvaro Duque

    (Kavli Institute for Neuroscience, Yale University School of Medicine)

  • Yuguo Yu

    (Kavli Institute for Neuroscience, Yale University School of Medicine)

  • David A. McCormick

    (Kavli Institute for Neuroscience, Yale University School of Medicine)

Abstract

A slice of the action Rapid communication between the neurons of the cerebral cortex involves propagation of an action potential, but the assumption that this is the sole form of cortical neuronal communication may need revision. Whole-cell recordings point to a possible alternative mechanism. Changes in membrane potential, such as those associated with synaptic activity, can also propagate along axons and can significantly alter the average amplitude of postsynaptic potentials. This type of neuronal signal may have important consequences, for instance in conditions such as sensory stimulation, the waking-to-sleeping transition and epileptic seizure, where large membrane potential changes occur.

Suggested Citation

  • Yousheng Shu & Andrea Hasenstaub & Alvaro Duque & Yuguo Yu & David A. McCormick, 2006. "Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential," Nature, Nature, vol. 441(7094), pages 761-765, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7094:d:10.1038_nature04720
    DOI: 10.1038/nature04720
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    Cited by:

    1. Biswa Sengupta & Simon Barry Laughlin & Jeremy Edward Niven, 2014. "Consequences of Converting Graded to Action Potentials upon Neural Information Coding and Energy Efficiency," PLOS Computational Biology, Public Library of Science, vol. 10(1), pages 1-18, January.
    2. Valmir C. Barbosa, 2017. "Information Integration from Distributed Threshold-Based Interactions," Complexity, Hindawi, vol. 2017, pages 1-14, January.

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