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Nuclear factor-κB in cancer development and progression

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  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction, University of California San Diego School of Medicine)

Abstract

Nuclear factor-κB (NF-κB) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-κB signalling also has a critical role in cancer development and progression. NF-κB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-κB might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.

Suggested Citation

  • Michael Karin, 2006. "Nuclear factor-κB in cancer development and progression," Nature, Nature, vol. 441(7092), pages 431-436, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7092:d:10.1038_nature04870
    DOI: 10.1038/nature04870
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    Cited by:

    1. Silvia Rodrigues Jardim & Lucila Marieta Perrotta de Souza & Heitor Siffert Pereira de Souza, 2023. "The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?," IJERPH, MDPI, vol. 20(4), pages 1-23, February.

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