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Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Author

Listed:
  • Jun Wang

    (Merck Research Laboratories)

  • Stephen M. Soisson

    (Merck Research Laboratories)

  • Katherine Young

    (Merck Research Laboratories)

  • Wesley Shoop

    (Merck Research Laboratories
    DuPont Stine-Haskell Research Center
    LL Silver Consulting)

  • Srinivas Kodali

    (Merck Research Laboratories)

  • Andrew Galgoci

    (Merck Research Laboratories)

  • Ronald Painter

    (Merck Research Laboratories)

  • Gopalakrishnan Parthasarathy

    (Merck Research Laboratories)

  • Yui S. Tang

    (Merck Research Laboratories)

  • Richard Cummings

    (Merck Research Laboratories)

  • Sookhee Ha

    (Merck Research Laboratories)

  • Karen Dorso

    (Merck Research Laboratories)

  • Mary Motyl

    (Merck Research Laboratories)

  • Hiranthi Jayasuriya

    (Merck Research Laboratories)

  • John Ondeyka

    (Merck Research Laboratories)

  • Kithsiri Herath

    (Merck Research Laboratories)

  • Chaowei Zhang

    (Merck Research Laboratories)

  • Lorraine Hernandez

    (Merck Research Laboratories)

  • John Allocco

    (Merck Research Laboratories)

  • Ángela Basilio

    (Merck Research Laboratories)

  • José R. Tormo

    (Merck Research Laboratories)

  • Olga Genilloud

    (Merck Research Laboratories)

  • Francisca Vicente

    (Merck Research Laboratories)

  • Fernando Pelaez

    (Merck Research Laboratories)

  • Lawrence Colwell

    (Merck Research Laboratories)

  • Sang Ho Lee

    (Merck Research Laboratories)

  • Bruce Michael

    (Merck Research Laboratories)

  • Thomas Felcetto

    (Merck Research Laboratories)

  • Charles Gill

    (Merck Research Laboratories)

  • Lynn L. Silver

    (Merck Research Laboratories
    DuPont Stine-Haskell Research Center
    LL Silver Consulting)

  • Jeffery D. Hermes

    (Merck Research Laboratories)

  • Ken Bartizal

    (Merck Research Laboratories)

  • John Barrett

    (Merck Research Laboratories)

  • Dennis Schmatz

    (Merck Research Laboratories)

  • Joseph W. Becker

    (Merck Research Laboratories)

  • Doris Cully

    (Merck Research Laboratories)

  • Sheo B. Singh

    (Merck Research Laboratories)

Abstract

New-wave antibiotics The worldwide spread of antibiotic resistance in pathogenic bacteria raises serious concerns that today's front-line antibiotics may become ineffective. So the discovery of a new class of compound with enormous potential as antibiotics is of great interest. Platensimycin is the first member of a novel class of natural products that selectively kills bacteria by inhibiting FabF/FabB proteins, a mechanism of action that is not used by any agents in clinical use. It is a potent antibiotic with broad-spectrum activity against Gram-positive bacteria, including clinically relevant drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. The future of platensimycins is considered in the News pages, and see the antimicrobials Web Focus on http://tinyurl.com/g8omx.

Suggested Citation

  • Jun Wang & Stephen M. Soisson & Katherine Young & Wesley Shoop & Srinivas Kodali & Andrew Galgoci & Ronald Painter & Gopalakrishnan Parthasarathy & Yui S. Tang & Richard Cummings & Sookhee Ha & Karen , 2006. "Platensimycin is a selective FabF inhibitor with potent antibiotic properties," Nature, Nature, vol. 441(7091), pages 358-361, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7091:d:10.1038_nature04784
    DOI: 10.1038/nature04784
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    Cited by:

    1. Zhijie Yang & Yijun Qiao & Emil Strøbech & Jens Preben Morth & Grit Walther & Tue Sparholt Jørgensen & Kah Yean Lum & Gundela Peschel & Miriam A. Rosenbaum & Viola Previtali & Mads Hartvig Clausen & M, 2024. "Alligamycin A, an antifungal β-lactone spiroketal macrolide from Streptomyces iranensis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Katherine A. Ray & Joshua D. Lutgens & Ramesh Bista & Jie Zhang & Ronak R. Desai & Melissa Hirsch & Takeshi Miyazawa & Antonio Cordova & Adrian T. Keatinge-Clay, 2024. "Assessing and harnessing updated polyketide synthase modules through combinatorial engineering," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Clara Lambert & Marine Gaillard & Paprapach Wongdontree & Caroline Bachmann & Antoine Hautcoeur & Karine Gloux & Thomas Guilbert & Celine Méhats & Bastien Prost & Audrey Solgadi & Sonia Abreu & Muriel, 2024. "The double-edged role of FASII regulator FabT in Streptococcus pyogenes infection," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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