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Lysyl oxidase is essential for hypoxia-induced metastasis

Author

Listed:
  • Janine T. Erler

    (Department of Radiation Oncology)

  • Kevin L. Bennewith

    (Department of Radiation Oncology)

  • Monica Nicolau

    (Department of Surgery)

  • Nadja Dornhöfer

    (University of Leipzig)

  • Christina Kong

    (Stanford University School of Medicine)

  • Quynh-Thu Le

    (Department of Radiation Oncology)

  • Jen-Tsan Ashley Chi

    (Duke University)

  • Stefanie S. Jeffrey

    (Department of Surgery)

  • Amato J. Giaccia

    (Department of Radiation Oncology)

Abstract

Hypoxia in tumours Tumours contain areas of low oxygen (hypoxia) because cancer cells grow and divide so fast that the blood vessels can't keep up with their oxygen requirement. Cells in a hypoxic region are prone to metastasis, but the reasons for this are unknown. Erler et al. have now discovered high levels of the enzyme lysyl oxidase (LOX) in hypoxic cells. High LOX content was associated with a poor prognosis in breast cancer patients. In mice, LOX inhibition reduced metastases, suggesting that it is a possible therapeutic target.

Suggested Citation

  • Janine T. Erler & Kevin L. Bennewith & Monica Nicolau & Nadja Dornhöfer & Christina Kong & Quynh-Thu Le & Jen-Tsan Ashley Chi & Stefanie S. Jeffrey & Amato J. Giaccia, 2006. "Lysyl oxidase is essential for hypoxia-induced metastasis," Nature, Nature, vol. 440(7088), pages 1222-1226, April.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7088:d:10.1038_nature04695
    DOI: 10.1038/nature04695
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    Cited by:

    1. Guang Cheng & Jianmin Li & Maoguen Zheng & Yinzhi Zhao & Jing Zhou & Wande Li, 2014. "NNK, a Tobacco-Specific Carcinogen, Inhibits the Expression of Lysyl Oxidase, a Tumor Suppressor," IJERPH, MDPI, vol. 12(1), pages 1-19, December.
    2. Victor Trevino & Mahlet G Tadesse & Marina Vannucci & Fatima Al-Shahrour & Philipp Antczak & Sarah Durant & Andreas Bikfalvi & Joaquin Dopazo & Moray J Campbell & Francesco Falciani, 2011. "Analysis of Normal-Tumour Tissue Interaction in Tumours: Prediction of Prostate Cancer Features from the Molecular Profile of Adjacent Normal Cells," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-13, March.
    3. Wande Li & Jing Zhou & Lijun Chen & Zhijun Luo & Yinzhi Zhao, 2011. "Lysyl Oxidase, A Critical Intra- and Extra-Cellular Target in the Lung for Cigarette Smoke Pathogenesis," IJERPH, MDPI, vol. 8(1), pages 1-24, January.
    4. Guoli Wang & Yanqing Shen & Guang Cheng & Haimei Bo & Jia Lin & Maogen Zheng & Jianmin Li & Yinzhi Zhao & Wande Li, 2016. "Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese Population," IJERPH, MDPI, vol. 13(7), pages 1-18, June.

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