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From molecule to malady

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  • Frances M. Ashcroft

    (University Laboratory of Physiology)

Abstract

Ion channels are membrane proteins, found in virtually all cells, that are of crucial physiological importance. In the past decade, an explosion in the number of crystal structures of ion channels has led to a marked increase in our understanding of how ion channels open and close, and select between permeant ions. There has been a parallel advance in research on channelopathies (diseases resulting from impaired channel function), and mutations in over 60 ion-channel genes are now known to cause human disease. Characterization of their functional consequences has afforded unprecedented and unexpected insights into ion-channel mechanisms and physiological roles.

Suggested Citation

  • Frances M. Ashcroft, 2006. "From molecule to malady," Nature, Nature, vol. 440(7083), pages 440-447, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7083:d:10.1038_nature04707
    DOI: 10.1038/nature04707
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    Cited by:

    1. Li Cao & I-Chun Chen & Zhen Li & Xiaowei Liu & Muhammad Mubashir & Reham Al Nuaimi & Zhiping Lai, 2022. "Switchable Na+ and K+ selectivity in an amino acid functionalized 2D covalent organic framework membrane," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Sonia Cavaliere & Bilal R Malik & James J L Hodge, 2013. "KCNQ Channels Regulate Age-Related Memory Impairment," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-8, April.

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