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Structural basis for the spectral difference in luciferase bioluminescence

Author

Listed:
  • Toru Nakatsu

    (RIKEN Harima Institute at SPring-8
    Kyoto University)

  • Susumu Ichiyama

    (RIKEN Harima Institute at SPring-8)

  • Jun Hiratake

    (Kyoto University)

  • Adrian Saldanha

    (Kyoto University)

  • Nobuyuki Kobashi

    (RIKEN Harima Institute at SPring-8)

  • Kanzo Sakata

    (Kyoto University)

  • Hiroaki Kato

    (RIKEN Harima Institute at SPring-8
    Kyoto University)

Abstract

Flying Colours Fireflies communicate using coloured light that is emitted when an electronically excited oxyluciferin species — made by the enzyme luciferase — relaxes to its groundstate. Point mutants of the enzyme can dramatically alter the colour of this ‘bioluminescence’, and though the luciferase X-ray crystal structure has been solved previously, the exact nature of this colour change had eluded biologists. Nakatsu et al. have now solved the X-ray structures of luciferase in several different states, and identify a specific conformational change in an isoleucine residue as the trigger for changes in bioluminescence colour.

Suggested Citation

  • Toru Nakatsu & Susumu Ichiyama & Jun Hiratake & Adrian Saldanha & Nobuyuki Kobashi & Kanzo Sakata & Hiroaki Kato, 2006. "Structural basis for the spectral difference in luciferase bioluminescence," Nature, Nature, vol. 440(7082), pages 372-376, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7082:d:10.1038_nature04542
    DOI: 10.1038/nature04542
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    Cited by:

    1. Mengdi Xie & Xiaojuan Lu & Han Wang & Xiaohua Fu & Lei Wang, 2023. "Large-Scale Biochar Incorporation Does Not Necessarily Promote the Carbon Sink of Estuarine Wetland Soil," Sustainability, MDPI, vol. 15(24), pages 1-14, December.
    2. Chuan Qin & Leonie G. Graf & Kilian Striska & Markus Janetzky & Norman Geist & Robin Specht & Sabrina Schulze & Gottfried J. Palm & Britta Girbardt & Babett Dörre & Leona Berndt & Stefan Kemnitz & Mar, 2024. "Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Ziyang Cao & Dongdong Li & Liang Zhao & Mengting Liu & Pengyue Ma & Yingli Luo & Xianzhu Yang, 2022. "Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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