IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v440y2006i7081d10.1038_nature04559.html
   My bibliography  Save this article

Expression profiling in primates reveals a rapid evolution of human transcription factors

Author

Listed:
  • Yoav Gilad

    (Yale University
    University of Chicago)

  • Alicia Oshlack

    (Walter and Eliza Hall Institute of Medical Research)

  • Gordon K. Smyth

    (Walter and Eliza Hall Institute of Medical Research)

  • Terence P. Speed

    (Walter and Eliza Hall Institute of Medical Research
    University of California)

  • Kevin P. White

    (Yale University)

Abstract

Express yourself Much has been written about the similarity between the human genome and those of the great apes. But as well as gene sequence, the manifestation of a genome in flesh and blood depends on gene expression patterns. Now using a multispecies cDNA array to compare human gene expression patterns to those in chimpanzees, orangutans and rhesus macaques, it is possible to identify individual genes subject to fast and slow expression-rate evolution. Some genes have been expressed at constant levels across the 70 million years of evolution encompassed by these species: these include genes associated with liver carcinoma, suggesting that other disease candidate genes might be found amongst genes with conserved expression. In contrast to these stable genes, positive selection in the human lineage occurs disproportionately on the very class of genes thought to be most likely to lead to divergence at the organismal level, the genes for transcription factors.

Suggested Citation

  • Yoav Gilad & Alicia Oshlack & Gordon K. Smyth & Terence P. Speed & Kevin P. White, 2006. "Expression profiling in primates reveals a rapid evolution of human transcription factors," Nature, Nature, vol. 440(7081), pages 242-245, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7081:d:10.1038_nature04559
    DOI: 10.1038/nature04559
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04559
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04559?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Adam Safron, 2019. "Multilevel evolutionary developmental optimization (MEDO): A theoretical framework for understanding preferences and selection dynamics," Papers 1910.13443, arXiv.org, revised Nov 2019.
    2. Su Yeon Kim & Jonathan K Pritchard, 2007. "Adaptive Evolution of Conserved Noncoding Elements in Mammals," PLOS Genetics, Public Library of Science, vol. 3(9), pages 1-15, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:440:y:2006:i:7081:d:10.1038_nature04559. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.