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V1 spinal neurons regulate the speed of vertebrate locomotor outputs

Author

Listed:
  • Simon Gosgnach

    (Molecular Neurobiology Laboratory)

  • Guillermo M. Lanuza

    (Molecular Neurobiology Laboratory)

  • Simon J. B. Butt

    (The Karolinska Institute
    New York University)

  • Harald Saueressig

    (Molecular Neurobiology Laboratory)

  • Ying Zhang

    (Molecular Neurobiology Laboratory)

  • Tomoko Velasquez

    (Molecular Neurobiology Laboratory)

  • Dieter Riethmacher

    (University of Hamburg)

  • Edward M. Callaway

    (The Salk Institute for Biological Studies)

  • Ole Kiehn

    (The Karolinska Institute)

  • Martyn Goulding

    (Molecular Neurobiology Laboratory)

Abstract

Walking in water Complex movements such as walking or swimming are produced by networks of nerve cells embedded in the spinal cord. A new study in mice has identified, for the first time, a subset of such nerve cells that controls the speed of locomotion. A unique combination of genetic and electrophysiological techniques reveals how these cells help set the rhythmic activity of spinal cord neurons. This work should be of interest to those studying neurological disorders. Intriguingly the V1 neurons that serve this function are conserved between swimming and walking vertebrates.

Suggested Citation

  • Simon Gosgnach & Guillermo M. Lanuza & Simon J. B. Butt & Harald Saueressig & Ying Zhang & Tomoko Velasquez & Dieter Riethmacher & Edward M. Callaway & Ole Kiehn & Martyn Goulding, 2006. "V1 spinal neurons regulate the speed of vertebrate locomotor outputs," Nature, Nature, vol. 440(7081), pages 215-219, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7081:d:10.1038_nature04545
    DOI: 10.1038/nature04545
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    Cited by:

    1. Santiago Mora & Anna Stuckert & Rasmus Huth Friis & Kimberly Pietersz & Gith Noes-Holt & Roser Montañana-Rosell & Haoyu Wang & Andreas Toft Sørensen & Raghavendra Selvan & Joost Verhaagen & Ilary Allo, 2024. "Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Li-Ju Hsu & Maëlle Bertho & Ole Kiehn, 2023. "Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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