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Identification of pathways regulating cell size and cell-cycle progression by RNAi

Author

Listed:
  • Mikael Björklund

    (University of Helsinki
    National Public Health Institute)

  • Minna Taipale

    (University of Helsinki
    National Public Health Institute)

  • Markku Varjosalo

    (University of Helsinki
    National Public Health Institute)

  • Juha Saharinen

    (National Public Health Institute
    Biomedicum Bioinformatics Unit, Biomedicum)

  • Juhani Lahdenperä

    (University of Helsinki)

  • Jussi Taipale

    (University of Helsinki
    University of Helsinki
    National Public Health Institute)

Abstract

Cell cycle paths Recent advances in our understanding of control of the eukaryotic cell cycle have relied on loss-of-function analyses of unicellular yeasts. But in multicellular organisms there are additional control mechanisms that regulate cell-cycle progression in the G1 phase, and specify the size of the organism and its constituent organs. An RNA interference (RNAi) screening for pathways regulating cell size and cell cycle in Drosophila has now identified genes that specifically control cell size, cytokinesis, and cell death/apoptosis. The panel of genes involved in cell-cycle control will serve as a basis for a systems biology approach to analysis of the metazoan cell cycle.

Suggested Citation

  • Mikael Björklund & Minna Taipale & Markku Varjosalo & Juha Saharinen & Juhani Lahdenperä & Jussi Taipale, 2006. "Identification of pathways regulating cell size and cell-cycle progression by RNAi," Nature, Nature, vol. 439(7079), pages 1009-1013, February.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7079:d:10.1038_nature04469
    DOI: 10.1038/nature04469
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    Cited by:

    1. Maxime Duval & Carlo Yague-Sanz & Tomasz W. Turowski & Elisabeth Petfalski & David Tollervey & François Bachand, 2023. "The conserved RNA-binding protein Seb1 promotes cotranscriptional ribosomal RNA processing by controlling RNA polymerase I progression," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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