IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v439y2006i7077d10.1038_nature04417.html
   My bibliography  Save this article

Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel

Author

Listed:
  • Yuriy Kirichok

    (Harvard Medical School Enders 1309)

  • Betsy Navarro

    (Harvard Medical School Enders 1309)

  • David E. Clapham

    (Harvard Medical School Enders 1309)

Abstract

Sperm ion flux pinned down Ion channels have an important role in the key physiological functions of mammalian sperm, but despite attempts over the past 20 years to record ion currents from sperm directly, no success had been achieved. Now a simple, reproducible patch-clamp method of recording sperm cell ion currents has been developed, and it reveals that the principal alkaline-activated Ca2+-selective channel in mouse spermatozoa is an alkaline-activated channel in the flagellum, containing the sperm-specific protein CatSper1.

Suggested Citation

  • Yuriy Kirichok & Betsy Navarro & David E. Clapham, 2006. "Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel," Nature, Nature, vol. 439(7077), pages 737-740, February.
  • Handle: RePEc:nat:nature:v:439:y:2006:i:7077:d:10.1038_nature04417
    DOI: 10.1038/nature04417
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04417
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature04417?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Julio C Chávez & José L de la Vega-Beltrán & Jessica Escoffier & Pablo E Visconti & Claudia L Treviño & Alberto Darszon & Lawrence Salkoff & Celia M Santi, 2013. "Ion Permeabilities in Mouse Sperm Reveal an External Trigger for SLO3-Dependent Hyperpolarization," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-13, April.
    2. Lifeng Tian & Hao Zhang & Shilong Yang & Anna Luo & Peter Muiruri Kamau & Jingmei Hu & Lei Luo & Ren Lai, 2023. "Vertebrate OTOP1 is also an alkali-activated channel," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Takafumi Kawai & Shin Morioka & Haruhiko Miyata & Rizki Tsari Andriani & Sharmin Akter & Gabriel Toma & Tatsuya Nakagawa & Yuki Oyama & Rie Iida-Norita & Junko Sasaki & Masahiko Watanabe & Kenji Sakim, 2024. "The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:439:y:2006:i:7077:d:10.1038_nature04417. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.