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Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

Author

Listed:
  • Koert J. Stittelaar

    (Erasmus MC)

  • Johan Neyts

    (K.U. Leuven)

  • Lieve Naesens

    (K.U. Leuven)

  • Geert van Amerongen

    (Erasmus MC
    Netherlands Vaccine Institute)

  • Rob F. van Lavieren

    (ViroClinics B.V.)

  • Antonin Holý

    (Academy of Sciences of the Czech Republic)

  • Erik De Clercq

    (K.U. Leuven)

  • Hubert G. M. Niesters

    (Erasmus MC)

  • Edwin Fries

    (Erasmus MC)

  • Chantal Maas

    (Erasmus MC)

  • Paul G. H. Mulder

    (Erasmus MC)

  • Ben A. M. van der Zeijst

    (Netherlands Vaccine Institute)

  • Albert D. M. E. Osterhaus

    (Erasmus MC)

Abstract

Smallpox virus: be prepared Several countries are stockpiling smallpox vaccine as a precaution against the possible use of vaccinia virus as a bioweapon. But although the vaccine is extremely effective at preventing smallpox infection, little is known about its efficacy as post-exposure vaccination in humans or in primates. A study in monkeys exposed to monkeypox virus shows that early treatment with antiviral drugs such as cidofovir is more effective than vaccination in reducing death rate and disease. Monkeypox is the ‘monkey equivalent’ of smallpox, so these data indicate that the use of antiviral drugs should be considered as an alternative or additional strategy for bioterrorist preparedness against smallpox.

Suggested Citation

  • Koert J. Stittelaar & Johan Neyts & Lieve Naesens & Geert van Amerongen & Rob F. van Lavieren & Antonin Holý & Erik De Clercq & Hubert G. M. Niesters & Edwin Fries & Chantal Maas & Paul G. H. Mulder &, 2006. "Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection," Nature, Nature, vol. 439(7077), pages 745-748, February.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7077:d:10.1038_nature04295
    DOI: 10.1038/nature04295
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    Cited by:

    1. Yiqi Huang & Valter Bergant & Vincent Grass & Quirin Emslander & M. Sabri Hamad & Philipp Hubel & Julia Mergner & Antonio Piras & Karsten Krey & Alexander Henrici & Rupert Öllinger & Yonas M. Tesfamar, 2024. "Multi-omics characterization of the monkeypox virus infection," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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