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Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

Author

Listed:
  • Gregor B. Adams

    (Center for Regenerative Medicine
    Harvard University)

  • Karissa T. Chabner

    (Center for Regenerative Medicine
    Harvard University)

  • Ian R. Alley

    (Center for Regenerative Medicine
    Harvard University)

  • Douglas P. Olson

    (Center for Regenerative Medicine)

  • Zbigniew M. Szczepiorkowski

    (Center for Regenerative Medicine
    Massachusetts General Hospital, Harvard Medical School
    Dartmouth Medical School)

  • Mark C. Poznansky

    (Center for Regenerative Medicine)

  • Claudine H. Kos

    (Renal Division)

  • Martin R. Pollak

    (Renal Division)

  • Edward M. Brown

    (Brigham and Women's Hospital, Harvard Medical School)

  • David T. Scadden

    (Center for Regenerative Medicine
    Harvard University)

Abstract

Stem-cell guidance Haematopoietic stem cells ‘home’ to the bone marrow during embryogenesis and after bone marrow transplants. With the exception of integrins, the molecules that mediate this process are largely unknown. Now Adams et al. have identified another factor essential for homing, a membrane-spanning molecule called calcium-sensing receptor (CaR). Cells lacking CaR divide normally, but the newly formed cells are unable to migrate and home to the bone marrow. This newly recognized participant in the localization and engraftment of stem cells provides a potential target for affecting that process.

Suggested Citation

  • Gregor B. Adams & Karissa T. Chabner & Ian R. Alley & Douglas P. Olson & Zbigniew M. Szczepiorkowski & Mark C. Poznansky & Claudine H. Kos & Martin R. Pollak & Edward M. Brown & David T. Scadden, 2006. "Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor," Nature, Nature, vol. 439(7076), pages 599-603, February.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7076:d:10.1038_nature04247
    DOI: 10.1038/nature04247
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    Cited by:

    1. S-C. A. Yeh & J. Hou & J. W. Wu & S. Yu & Y. Zhang & K. D. Belfield & F. D. Camargo & C. P. Lin, 2022. "Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Raquel S. Pereira & Rahul Kumar & Alessia Cais & Lara Paulini & Alisa Kahler & Jimena Bravo & Valentina R. Minciacchi & Theresa Krack & Eric Kowarz & Costanza Zanetti & Parimala Sonika Godavarthy & Fa, 2023. "Distinct and targetable role of calcium-sensing receptor in leukaemia," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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