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Architecture of ribonucleoprotein complexes in influenza A virus particles

Author

Listed:
  • Takeshi Noda

    (University of Tokyo
    Graduate School of Veterinary Medicine, Hokkaido University
    Japan Science and Technology Agency)

  • Hiroshi Sagara

    (Institute of Medical Science, University of Tokyo)

  • Albert Yen

    (Karolinska Institute)

  • Ayato Takada

    (Japan Science and Technology Agency
    University of Tokyo
    Hokkaido University)

  • Hiroshi Kida

    (Graduate School of Veterinary Medicine, Hokkaido University)

  • R. Holland Cheng

    (Karolinska Institute
    University of California)

  • Yoshihiro Kawaoka

    (University of Tokyo
    Japan Science and Technology Agency
    University of Tokyo
    School of Veterinary Medicine, University of Wisconsin-Madison)

Abstract

Flu virus: pieces of eight The influenza virus is unusual in that its genome is fragmented, and the mechanism that reconstitutes the genome in viral progeny is largely unknown. A new electron microscopy study reveals that each budding influenza virus particle contains a central rod of genetic material, surrounded by seven peripheral rods in a reproducible pattern. Prior to this work it was commonly thought that viral particles consisted of eight randomly selected RNA segments. This high level of organization could be a weak point in the virus's defences that might be exploited by new antiviral drugs.

Suggested Citation

  • Takeshi Noda & Hiroshi Sagara & Albert Yen & Ayato Takada & Hiroshi Kida & R. Holland Cheng & Yoshihiro Kawaoka, 2006. "Architecture of ribonucleoprotein complexes in influenza A virus particles," Nature, Nature, vol. 439(7075), pages 490-492, January.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7075:d:10.1038_nature04378
    DOI: 10.1038/nature04378
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    Cited by:

    1. Timothy D Majarian & Robert F Murphy & Seema S Lakdawala, 2019. "Learning the sequence of influenza A genome assembly during viral replication using point process models and fluorescence in situ hybridization," PLOS Computational Biology, Public Library of Science, vol. 15(1), pages 1-20, January.

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