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Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population

Author

Listed:
  • Marco Vignuzzi

    (University of California)

  • Jeffrey K. Stone

    (University of California)

  • Jamie J. Arnold

    (Pennsylvania State University)

  • Craig E. Cameron

    (Pennsylvania State University)

  • Raul Andino

    (University of California)

Abstract

Viruses, where wrong is right The replication of RNA viruses is associated with a higher mutation rate than is seen in organisms using DNA as their genetic material. This can produce nonviable individuals but also, it has been suggested, some useful variation that could enhance the fitness of virus populations by allowing them to adapt to changing environments encountered during infection. Until now there has been no experimental support for this suggestion, known as the ‘quasispecies’ hypothesis. But now a search for viruses that copy their genome too accurately has provided support for this idea. Poliovirus isolates carrying a ‘super accurate’ RNA polymerase are less varied and less infectious than normal viruses. These results could have implications for the development of antiviral drugs.

Suggested Citation

  • Marco Vignuzzi & Jeffrey K. Stone & Jamie J. Arnold & Craig E. Cameron & Raul Andino, 2006. "Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population," Nature, Nature, vol. 439(7074), pages 344-348, January.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7074:d:10.1038_nature04388
    DOI: 10.1038/nature04388
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    Cited by:

    1. Saakian, David B. & Ghazaryan, Makar & Bratus, Alexander & Hu, Chin-Kun, 2017. "Biological evolution model with conditional mutation rates," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 474(C), pages 32-38.
    2. Adam Catching & Ming Yeh & Simone Bianco & Sara Capponi & Raul Andino, 2023. "A tradeoff between enterovirus A71 particle stability and cell entry," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Nikolai Bessonov & Gennady Bocharov & Andreas Meyerhans & Vladimir Popov & Vitaly Volpert, 2020. "Nonlocal Reaction–Diffusion Model of Viral Evolution: Emergence of Virus Strains," Mathematics, MDPI, vol. 8(1), pages 1-20, January.
    4. Radboud J. Duintjer Tebbens & Mark A. Pallansch & Jong‐Hoon Kim & Cara C. Burns & Olen M. Kew & M. Steven Oberste & Ousmane M. Diop & Steven G.F. Wassilak & Stephen L. Cochi & Kimberly M. Thompson, 2013. "Oral Poliovirus Vaccine Evolution and Insights Relevant to Modeling the Risks of Circulating Vaccine‐Derived Polioviruses (cVDPVs)," Risk Analysis, John Wiley & Sons, vol. 33(4), pages 680-702, April.
    5. Wopke van der Werf & Lia Hemerik & Just M Vlak & Mark P Zwart, 2011. "Heterogeneous Host Susceptibility Enhances Prevalence of Mixed-Genotype Micro-Parasite Infections," PLOS Computational Biology, Public Library of Science, vol. 7(6), pages 1-15, June.

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