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Planar cell polarity signalling couples cell division and morphogenesis during neurulation

Author

Listed:
  • Brian Ciruna

    (New York University School of Medicine
    Toronto Medical Discovery Tower)

  • Andreas Jenny

    (Cellular and Developmental Biology)

  • Diana Lee

    (New York University School of Medicine)

  • Marek Mlodzik

    (Cellular and Developmental Biology)

  • Alexander F. Schier

    (New York University School of Medicine
    Harvard University)

Abstract

Neural tube defects Neural tube closure defects like spina bifida and anencephaly afflict 1 in 1,000 newborns, but the underlying causes of these congenital malformations are largely unknown. Studies in animal models have implicated the planar cell polarity (PCP) signalling pathway as playing a role in neural tube closure during embryogenesis. Ciruna et al. have now uncovered a new mechanism for this process, whereby the PCP protein ‘Van Gogh-like 2’ polarizes neural progenitors along the anterior–posterior axis. This protein is required for intercalation of daughter cells into an intermediate structure called the neural keel formed prior to neural tube closure. The PCP pathway appears to couple cell division to morphogenesis, and malfunction in this system could be a previously unrecognized cause of neural tube closure defects.

Suggested Citation

  • Brian Ciruna & Andreas Jenny & Diana Lee & Marek Mlodzik & Alexander F. Schier, 2006. "Planar cell polarity signalling couples cell division and morphogenesis during neurulation," Nature, Nature, vol. 439(7073), pages 220-224, January.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7073:d:10.1038_nature04375
    DOI: 10.1038/nature04375
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    Cited by:

    1. Maria Jussila & Curtis W. Boswell & Nigel W. Griffiths & Patrick G. Pumputis & Brian Ciruna, 2022. "Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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