IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v438y2005i7071d10.1038_nature04302.html
   My bibliography  Save this article

NMDA receptors are expressed in oligodendrocytes and activated in ischaemia

Author

Listed:
  • Ragnhildur Káradóttir

    (University College London)

  • Pauline Cavelier

    (University College London)

  • Linda H. Bergersen

    (University of Oslo)

  • David Attwell

    (University College London)

Abstract

Glial glutamate receptors Oligodendrocytes are the cells in the white matter of the central nervous system that produce and maintain the myelin sheath that insulates the impulse-carrying axon. They are damaged by the neurotransmitter glutamate in diseases as diverse as cerebral palsy, spinal cord injury, stroke and multiple sclerosis. It has become widely accepted that, unlike neurons which are mainly killed by glutamate acting on NMDA receptors, oligodendrocytes lack these receptors and are killed solely by glutamate acting on AMPA/kainate receptors. This thinking has guided therapeutic strategies, but it seems that the underlying assumption about glutamate receptor types may be wrong. Three papers published this week make a convincing case for the presence of NMDA receptors in oligodendrocytes, and for their involvement in causing damage to the cells in injury and disease. This will refocus attention on NMDA receptors as an important therapeutic target for drugs in a variety of neurological disorders.

Suggested Citation

  • Ragnhildur Káradóttir & Pauline Cavelier & Linda H. Bergersen & David Attwell, 2005. "NMDA receptors are expressed in oligodendrocytes and activated in ischaemia," Nature, Nature, vol. 438(7071), pages 1162-1166, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7071:d:10.1038_nature04302
    DOI: 10.1038/nature04302
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04302
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04302?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chang Hoon Cho & Ilana Vasilisa Deyneko & Dylann Cordova-Martinez & Juan Vazquez & Anne S. Maguire & Jenny R. Diaz & Abigail U. Carbonell & Jaafar O. Tindi & Min-Hui Cui & Roman Fleysher & Sophie Molh, 2023. "ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:438:y:2005:i:7071:d:10.1038_nature04302. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.