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Retinal angiogenesis in development and disease

Author

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  • Ray F. Gariano

    (Stanford University School of Medicine)

  • Thomas W. Gardner

    (Penn State College of Medicine)

Abstract

The retina has long been regarded as ‘an approachable part of the brain’ for investigating neurosensory processes. Cell biologists are now capitalizing on the accessibility of the retina to investigate important aspects of developmental angiogenesis, including how it relates to neuronal and glial development, morphogenesis, oxygen sensing and progenitor cells. Pathological angiogenesis also occurs in the retina and is a major feature of leading blinding diseases, particularly diabetic retinopathy. The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases.

Suggested Citation

  • Ray F. Gariano & Thomas W. Gardner, 2005. "Retinal angiogenesis in development and disease," Nature, Nature, vol. 438(7070), pages 960-966, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7070:d:10.1038_nature04482
    DOI: 10.1038/nature04482
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    Cited by:

    1. Sara G. Romeo & Ilaria Secco & Edoardo Schneider & Christina M. Reumiller & Celio X. C. Santos & Anna Zoccarato & Vishal Musale & Aman Pooni & Xiaoke Yin & Konstantinos Theofilatos & Silvia Cellone Tr, 2023. "Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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