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Lymphangiogenesis in development and human disease

Author

Listed:
  • Kari Alitalo

    (Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer, Research
    University of Helsinki)

  • Tuomas Tammela

    (Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer, Research
    University of Helsinki)

  • Tatiana V. Petrova

    (Development and Differentiation Laboratory, Molecular/Cancer Biology Program, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital
    University of Helsinki)

Abstract

The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood. Lymphatic vessels are also an essential part of the body's immune defence. They have an important role in the pathogenesis of several diseases, such as cancer, lymphoedema and various inflammatory conditions. Recent biological and technological developments in lymphatic vascular biology will lead to a better understanding and treatment of these diseases.

Suggested Citation

  • Kari Alitalo & Tuomas Tammela & Tatiana V. Petrova, 2005. "Lymphangiogenesis in development and human disease," Nature, Nature, vol. 438(7070), pages 946-953, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7070:d:10.1038_nature04480
    DOI: 10.1038/nature04480
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    Cited by:

    1. Li, Li, 2015. "Bifurcation and chaos in a discrete physiological control system," Applied Mathematics and Computation, Elsevier, vol. 252(C), pages 397-404.
    2. Nieves Montenegro-Navarro & Claudia García-Báez & Melissa García-Caballero, 2023. "Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathology," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. A. Zamora & M. Nougué & L. Verdu & E. Balzan & T. Draia-Nicolau & E. Benuzzi & F. Pujol & V. Baillif & E. Lacazette & F. Morfoisse & J. Galitzky & A. Bouloumié & M. Dubourdeau & B. Chaput & N. Fazille, 2024. "15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-β," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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