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A histone H3 methyltransferase controls epigenetic events required for meiotic prophase

Author

Listed:
  • Katsuhiko Hayashi

    (Osaka Medical Center for Maternal and Child Health
    CREST, Japan Science and Technology Agency (JST)
    University of Cambridge)

  • Kayo Yoshida

    (Graduate School of Medicine, Osaka City University)

  • Yasuhisa Matsui

    (Osaka Medical Center for Maternal and Child Health
    CREST, Japan Science and Technology Agency (JST)
    Aging and Cancer, Tohoku University)

Abstract

Managing meiosis Meiosis is a unique cell division that is necessary for sexual reproduction; it produces functional haploid gametes and shuffles genomic information. Progression through meiosis is controlled by the proper orchestration of a number of meiotic genes. A candidate gene for regulating meiotic gene expression has now been identified. Meisetz, encoding a meiosis-specific histone H3 lysine 4-specific trimethyltransferase, is essential for meiotic recombination between homologous chromosomes in mice. Meisetz has essential functions in spermatocytes through epigenetic modification of chromatin, the first instance of a gene regulating epigenetic control of gene expression during meiotic progression.

Suggested Citation

  • Katsuhiko Hayashi & Kayo Yoshida & Yasuhisa Matsui, 2005. "A histone H3 methyltransferase controls epigenetic events required for meiotic prophase," Nature, Nature, vol. 438(7066), pages 374-378, November.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7066:d:10.1038_nature04112
    DOI: 10.1038/nature04112
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    Cited by:

    1. Michelle K. Y. Seah & Brenda Y. Han & Yan Huang & Louise J. H. Rasmussen & Andrina J. Stäubli & Judith Bello-Rodríguez & Andrew Chi-Ho Chan & Maxime Gasnier & Heike Wollmann & Ernesto Guccione & Danie, 2025. "Maternal PRDM10 activates essential genes for oocyte-to-embryo transition," Nature Communications, Nature, vol. 16(1), pages 1-13, December.

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