IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v437y2005i7063d10.1038_nature04108.html
   My bibliography  Save this article

Wnt signalling regulates adult hippocampal neurogenesis

Author

Listed:
  • Dieter-Chichung Lie

    (The Salk Institute
    Institute of Developmental Genetics)

  • Sophia A. Colamarino

    (The Salk Institute)

  • Hong-Jun Song

    (The Salk Institute
    Johns Hopkins University School of Medicine)

  • Laurent Désiré

    (The Salk Institute)

  • Helena Mira

    (The Salk Institute)

  • Antonella Consiglio

    (The Salk Institute)

  • Edward S. Lein

    (The Salk Institute)

  • Sebastian Jessberger

    (The Salk Institute)

  • Heather Lansford

    (The Salk Institute)

  • Alejandro R. Dearie

    (The Salk Institute)

  • Fred H. Gage

    (The Salk Institute)

Abstract

Wnt3 spells neuron Neural stem/progenitor cells in the adult brain are able to generate both the brain's major cell types: glial cells, which are non-neuronal, and the active nerve cells or neurons. Neurons are produced in just two regions of the brain. Lie et al. have now identified a protein family that instructs the adult neural stem cells to produce neurons, rather than glial cells. The signal molecule Wnt3 is shown to be crucial for the production of neurons in the adult hippocampus, a region believed to be involved in learning and memory formation. Ultimately these studies may help develop therapies to repair brain damage caused by disease or trauma.

Suggested Citation

  • Dieter-Chichung Lie & Sophia A. Colamarino & Hong-Jun Song & Laurent Désiré & Helena Mira & Antonella Consiglio & Edward S. Lein & Sebastian Jessberger & Heather Lansford & Alejandro R. Dearie & Fred , 2005. "Wnt signalling regulates adult hippocampal neurogenesis," Nature, Nature, vol. 437(7063), pages 1370-1375, October.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7063:d:10.1038_nature04108
    DOI: 10.1038/nature04108
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04108
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04108?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chiara Scopa & Samantha M. Barnada & Maria E. Cicardi & Mo Singer & Davide Trotti & Marco Trizzino, 2023. "JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Bo Zhang & Chen Zhao & Wenchen Shen & Wei Li & Yue Zheng & Xiangfei Kong & Junbao Wang & Xudong Wu & Tao Zeng & Ying Liu & Yan Zhou, 2023. "KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:437:y:2005:i:7063:d:10.1038_nature04108. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.