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Wnt signalling regulates adult hippocampal neurogenesis

Author

Listed:
  • Dieter-Chichung Lie

    (The Salk Institute
    Institute of Developmental Genetics)

  • Sophia A. Colamarino

    (The Salk Institute)

  • Hong-Jun Song

    (The Salk Institute
    Johns Hopkins University School of Medicine)

  • Laurent Désiré

    (The Salk Institute)

  • Helena Mira

    (The Salk Institute)

  • Antonella Consiglio

    (The Salk Institute)

  • Edward S. Lein

    (The Salk Institute)

  • Sebastian Jessberger

    (The Salk Institute)

  • Heather Lansford

    (The Salk Institute)

  • Alejandro R. Dearie

    (The Salk Institute)

  • Fred H. Gage

    (The Salk Institute)

Abstract

Wnt3 spells neuron Neural stem/progenitor cells in the adult brain are able to generate both the brain's major cell types: glial cells, which are non-neuronal, and the active nerve cells or neurons. Neurons are produced in just two regions of the brain. Lie et al. have now identified a protein family that instructs the adult neural stem cells to produce neurons, rather than glial cells. The signal molecule Wnt3 is shown to be crucial for the production of neurons in the adult hippocampus, a region believed to be involved in learning and memory formation. Ultimately these studies may help develop therapies to repair brain damage caused by disease or trauma.

Suggested Citation

  • Dieter-Chichung Lie & Sophia A. Colamarino & Hong-Jun Song & Laurent Désiré & Helena Mira & Antonella Consiglio & Edward S. Lein & Sebastian Jessberger & Heather Lansford & Alejandro R. Dearie & Fred , 2005. "Wnt signalling regulates adult hippocampal neurogenesis," Nature, Nature, vol. 437(7063), pages 1370-1375, October.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7063:d:10.1038_nature04108
    DOI: 10.1038/nature04108
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    Cited by:

    1. Bo Zhang & Chen Zhao & Wenchen Shen & Wei Li & Yue Zheng & Xiangfei Kong & Junbao Wang & Xudong Wu & Tao Zeng & Ying Liu & Yan Zhou, 2023. "KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Chiara Scopa & Samantha M. Barnada & Maria E. Cicardi & Mo Singer & Davide Trotti & Marco Trizzino, 2023. "JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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