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Isolation of drug-resistant H5N1 virus

Author

Listed:
  • Q. Mai Le

    (National Institute of Hygiene and Epidemiology)

  • Maki Kiso

    (Institute of Medical Science, University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi)

  • Kazuhiko Someya

    (Institute of Medical Science, University of Tokyo
    Daiichi Pharmaceutical)

  • Yuko T. Sakai

    (Institute of Medical Science, University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi)

  • T. Hien Nguyen

    (National Institute of Hygiene and Epidemiology)

  • Khan H. L. Nguyen

    (National Institute of Hygiene and Epidemiology)

  • N. Dinh Pham

    (National Institute of Hygiene and Epidemiology)

  • Ha H. Ngyen

    (National Institute for Clinical Research in Tropical Medicine)

  • Shinya Yamada

    (Institute of Medical Science, University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi)

  • Yukiko Muramoto

    (Institute of Medical Science, University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi)

  • Taisuke Horimoto

    (Institute of Medical Science, University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi)

  • Ayato Takada

    (Institute of Medical Science, University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi)

  • Hideo Goto

    (Institute of Medical Science, University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi)

  • Takashi Suzuki

    (Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi
    University of Shizuoka, School of Pharmaceutical Sciences and COE Program in the 21st Century, Yada)

  • Yasuo Suzuki

    (Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi
    University of Shizuoka, School of Pharmaceutical Sciences and COE Program in the 21st Century, Yada)

  • Yoshihiro Kawaoka

    (Institute of Medical Science, University of Tokyo
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi
    International Research Center for Infectious Diseases
    School of Veterinary Medicine, University of Wisconsin, Madison)

Abstract

Resistant h5n1 The full report on an H5N1 avian flu virus isolate resistant to Tamiflu (oseltamivir) has added to concerns about preparations for a flu pandemic. The virus was from a Vietnamese girl given the drug as both prophylaxis and to treat infection. The discovery suggests it may be time to review dose rates for Tamiflu, and for governments to stockpile Relenza as well as Tamiflu.

Suggested Citation

  • Q. Mai Le & Maki Kiso & Kazuhiko Someya & Yuko T. Sakai & T. Hien Nguyen & Khan H. L. Nguyen & N. Dinh Pham & Ha H. Ngyen & Shinya Yamada & Yukiko Muramoto & Taisuke Horimoto & Ayato Takada & Hideo Go, 2005. "Isolation of drug-resistant H5N1 virus," Nature, Nature, vol. 437(7062), pages 1108-1108, October.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7062:d:10.1038_4371108a
    DOI: 10.1038/4371108a
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    Cited by:

    1. George J Milne & Nilimesh Halder & Joel K Kelso, 2013. "The Cost Effectiveness of Pandemic Influenza Interventions: A Pandemic Severity Based Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-16, April.
    2. Boni, Maciej F. & Galvani, Alison P. & Wickelgren, Abraham L. & Malani, Anup, 2013. "Economic epidemiology of avian influenza on smallholder poultry farms," Theoretical Population Biology, Elsevier, vol. 90(C), pages 135-144.

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