IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v437y2005i7061d10.1038_nature04117.html
   My bibliography  Save this article

Vertebrate Smoothened functions at the primary cilium

Author

Listed:
  • Kevin C. Corbit

    (Developmental and Stem Cell Biology Program
    Diabetes Center)

  • Pia Aanstad

    (Developmental and Stem Cell Biology Program
    Diabetes Center
    University of California)

  • Veena Singla

    (Developmental and Stem Cell Biology Program
    Diabetes Center)

  • Andrew R. Norman

    (Developmental and Stem Cell Biology Program
    Diabetes Center)

  • Didier Y. R. Stainier

    (Developmental and Stem Cell Biology Program
    Diabetes Center
    University of California)

  • Jeremy F. Reiter

    (Developmental and Stem Cell Biology Program
    Diabetes Center)

Abstract

Cilia make sense The primary cilium is a mysterious organelle found on vertebrate cells in the interphase, the point in the cell cycle between two cell divisions when DNA is replicated and individual chromosomes are not distinguishable. The discovery that Smoothened, part of the Hedgehog signalling pathway, functions at the primary cilium supports the theory that the cilium acts as an antenna through which various signals are sensed and transduced. These signals may play an important role in development and disease.

Suggested Citation

  • Kevin C. Corbit & Pia Aanstad & Veena Singla & Andrew R. Norman & Didier Y. R. Stainier & Jeremy F. Reiter, 2005. "Vertebrate Smoothened functions at the primary cilium," Nature, Nature, vol. 437(7061), pages 1018-1021, October.
  • Handle: RePEc:nat:nature:v:437:y:2005:i:7061:d:10.1038_nature04117
    DOI: 10.1038/nature04117
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04117
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature04117?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ying Yang & Pekka Paivinen & Chang Xie & Alexis Leigh Krup & Tomi P. Makela & Keith E. Mostov & Jeremy F. Reiter, 2021. "Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Xiaoliang Liu & Patricia T. Yam & Sabrina Schlienger & Eva Cai & Jingyi Zhang & Wei-Ju Chen & Oscar Torres Gutierrez & Vanesa Jimenez Amilburu & Vasanth Ramamurthy & Alice Y. Ting & Tess C. Branon & M, 2024. "Numb positively regulates Hedgehog signaling at the ciliary pocket," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:437:y:2005:i:7061:d:10.1038_nature04117. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.