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Vertebrate Smoothened functions at the primary cilium

Author

Listed:
  • Kevin C. Corbit

    (Developmental and Stem Cell Biology Program
    Diabetes Center)

  • Pia Aanstad

    (Developmental and Stem Cell Biology Program
    Diabetes Center
    University of California)

  • Veena Singla

    (Developmental and Stem Cell Biology Program
    Diabetes Center)

  • Andrew R. Norman

    (Developmental and Stem Cell Biology Program
    Diabetes Center)

  • Didier Y. R. Stainier

    (Developmental and Stem Cell Biology Program
    Diabetes Center
    University of California)

  • Jeremy F. Reiter

    (Developmental and Stem Cell Biology Program
    Diabetes Center)

Abstract

Cilia make sense The primary cilium is a mysterious organelle found on vertebrate cells in the interphase, the point in the cell cycle between two cell divisions when DNA is replicated and individual chromosomes are not distinguishable. The discovery that Smoothened, part of the Hedgehog signalling pathway, functions at the primary cilium supports the theory that the cilium acts as an antenna through which various signals are sensed and transduced. These signals may play an important role in development and disease.

Suggested Citation

  • Kevin C. Corbit & Pia Aanstad & Veena Singla & Andrew R. Norman & Didier Y. R. Stainier & Jeremy F. Reiter, 2005. "Vertebrate Smoothened functions at the primary cilium," Nature, Nature, vol. 437(7061), pages 1018-1021, October.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7061:d:10.1038_nature04117
    DOI: 10.1038/nature04117
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    Cited by:

    1. Xiaoliang Liu & Patricia T. Yam & Sabrina Schlienger & Eva Cai & Jingyi Zhang & Wei-Ju Chen & Oscar Torres Gutierrez & Vanesa Jimenez Amilburu & Vasanth Ramamurthy & Alice Y. Ting & Tess C. Branon & M, 2024. "Numb positively regulates Hedgehog signaling at the ciliary pocket," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Ying Yang & Pekka Paivinen & Chang Xie & Alexis Leigh Krup & Tomi P. Makela & Keith E. Mostov & Jeremy F. Reiter, 2021. "Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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