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Aminoglycoside antibiotics induce bacterial biofilm formation

Author

Listed:
  • Lucas R. Hoffman

    (University of Washington)

  • David A. D'Argenio

    (University of Washington)

  • Michael J. MacCoss

    (University of Washington)

  • Zhaoying Zhang

    (Rutgers University)

  • Roger A. Jones

    (Rutgers University)

  • Samuel I. Miller

    (University of Washington
    University of Washington
    University of Washington)

Abstract

Antibiotic-induced biofilms Bacteria commonly form adherent cell aggregates or biofilms in which they become resistant to killing by antibiotics. Now in a surprising development, commonly used aminoglycoside antibiotics at subinhibitory concentrations are shown to induce biofilm formation in Pseudomonas aeruginosa and Escherichia coli. Since most antibiotics are made by bacteria, such defences probably evolved as a result of microbial competition. A candidate antibiotic receptor that acts as a trigger for biofilm formation has been identified. Blocking this receptor could help to overcome antibiotic resistance and improve the efficacy of current therapy.

Suggested Citation

  • Lucas R. Hoffman & David A. D'Argenio & Michael J. MacCoss & Zhaoying Zhang & Roger A. Jones & Samuel I. Miller, 2005. "Aminoglycoside antibiotics induce bacterial biofilm formation," Nature, Nature, vol. 436(7054), pages 1171-1175, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7054:d:10.1038_nature03912
    DOI: 10.1038/nature03912
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    Cited by:

    1. Godelieve Alice Goossens, 2015. "Flushing and Locking of Venous Catheters: Available Evidence and Evidence Deficit," Nursing Research and Practice, Hindawi, vol. 2015, pages 1-12, May.
    2. Jarmila Pazlarová & Sabina Purkrtová & Jana Babuliková & Kateřina Demnerová, 2014. "Effects of ampicillin and vancomycin on Staphylococcus aureus biofilms," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 32(2), pages 137-144.
    3. Jayita Goswami, 2017. "Quorum Sensing by Super Bugs and their Resistance to Antibiotics, a Short Review," Global Journal of Pharmacy & Pharmaceutical Sciences, Juniper Publishers Inc., vol. 3(3), pages 67-73, August.
    4. Ali Raza & Abdul Ghaffar Qamar & Asad Manzoor & Misbah Ijaz & Khizar Hayat & Tayyab Rehman & Muhammad Shakeel & Ghulam. Muhammad, 2017. "Detection Of Biofilm Production By Staphylococcus Aureus And In-Vitro Inhibition Of Biofilm Using Serum Antibodies," Matrix Science Medica (MSM), Zibeline International Publishing, vol. 1(2), pages 7-10, November.

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